Footnotes

• Contributors JF made substantial contributions to the article in the conception and design of the study, drafting the article and revising it critically for important intellectual content. DW and MD made substantial contributions in the conception and design of the study, acquisition and analysis of data and interpretation of data. SCC made substantial contributions in the conception and design of the study and revising the article critically for important intellectual content. All authors have approved the final version of the article to be submitted.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests JF: has participated in a BD Medical Expert Advisory Board and received an honorarium. DW: has received educational sponsorship from Calea/Fresenius-Kabi. MD: none declared. SCC: has received honoraria and participated in advisory boards for Eli Lilley, honoria from Baxter and educational sponsorship from Shire and Calea/Fresenius-Kabi

• Patient consent for publication Not required.

• Provenance and peer review Not commissioned; internally peer reviewed.