Background End‐of‐life discussions are associated with improved quality of care for
patients. In the UK, the General Medical Council outlines a requirement for medical …

Background The propensity for certain analgesics to cause sedation is well documented, yet
physician–patient dialogue does not routinely include pre-emptive exploration of …

To the Editor: We read with great interest the EQUIMETH2 study by Poulain et al. 1 that
compared two methods of methadone titration in the treatment for cancer-related pain …

Opioid-induced constipation (OIC) is common and can significantly affect quality of life.
Naloxegol and methylnaltrexone are peripherally acting µ-opioid receptor antagonists …

Background Methadone is a synthetic opioid which has actions on both mu and NMDA
receptors and can be used in pain management. A service evaluation on the use of …

Background 'Five Priorities of Care'requires an individualised plan for hydration at end of life
and discussion with patients/those important to them. However there is little research …

Background In keeping with the 'Care of dying adults in the last days of life'NICE guidelines,
inpatients are consistently prescribed anticipatory medications. However, decisions for …

Method Five years of retrospective radiotherapy data from the regional Leeds Cancer Centre
was filtered (94% sensitive, 90% specific) to achieve a palliative cohort with CIBP …

Background Ketamine is a potent analgesic with potentially serious adverse effects (eg
dysphoria, bladder dysfunction), being used in palliative medicine. Its evidence base is …

Background Opioid-induced constipation is common in palliative care. The evidence base
for most laxatives and rectal interventions is poor, but for sc methylnaltrexone is good …