User profiles for "author:Steven Paul"
Steven M. PaulProfessor at Washington University of St Louis Verified email at karunatx.com Cited by 82523 |
How to improve R&D productivity: the pharmaceutical industry's grand challenge
SM Paul, DS Mytelka, CT Dunwiddie… - Nature reviews Drug …, 2010 - nature.com
The pharmaceutical industry is under growing pressure from a range of environmental
issues, including major losses of revenue owing to patent expirations, increasingly cost …
issues, including major losses of revenue owing to patent expirations, increasingly cost …
Neuroactive steroids
SM Paul, RH Purdy - The FASEB Journal, 1992 - Wiley Online Library
Neuroactive steroids are natural or synthetic steroids that rapidly alter the excitability of
neurons by binding to membrane‐bound receptors such as those for inhibitory and (or) …
neurons by binding to membrane‐bound receptors such as those for inhibitory and (or) …
Receptors for the age of anxiety: pharmacology of the benzodiazepines
JF Tallman, SM Paul, P Skolnick, DW Gallager - Science, 1980 - science.org
Investigation of the actions of the benzodiazepines has provided insights into the
neurochemical mechanisms underlying anxiety, seizures, muscle relaxation, and sedation …
neurochemical mechanisms underlying anxiety, seizures, muscle relaxation, and sedation …
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
MD Majewska, NL Harrison, RD Schwartz, JL Barker… - Science, 1986 - science.org
Two metabolites of the steroid hormones progesterone and deoxycorticosterone, 3α-hydroxy-
5α-dihydroprogesterone and 3α, 5α-tetrahydrodeoxycorticosterone, are potent barbiturate …
5α-dihydroprogesterone and 3α, 5α-tetrahydrodeoxycorticosterone, are potent barbiturate …
[HTML][HTML] Synaptic activity regulates interstitial fluid amyloid-β levels in vivo
Aggregation of the amyloid-β (Aβ) peptide in the extracellular space of the brain is central to
Alzheimer's disease pathogenesis. Aβ aggregation is concentration dependent and brain …
Alzheimer's disease pathogenesis. Aβ aggregation is concentration dependent and brain …
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
RB DeMattos, KR Bales, DJ Cummins… - Proceedings of the …, 2001 - National Acad Sciences
Active immunization with the amyloid β (Aβ) peptide has been shown to decrease brain Aβ
deposition in transgenic mouse models of Alzheimer's disease and certain peripherally …
deposition in transgenic mouse models of Alzheimer's disease and certain peripherally …
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance
JM Castellano, J Kim, FR Stewart, H Jiang… - Science translational …, 2011 - science.org
The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset,
sporadic Alzheimer's disease (AD). The APOE ε4 allele markedly increases AD risk and …
sporadic Alzheimer's disease (AD). The APOE ε4 allele markedly increases AD risk and …
Nicotinic binding in rat brain: autoradiographic comparison of [3H] acetylcholine,[3H] nicotine, and [125I]-alpha-bungarotoxin
Three radioligands have been commonly used to label putative nicotinic cholinoceptors in
the mammalian central nervous system: the agonists [3H] nicotine and [3H] acetylcholine …
the mammalian central nervous system: the agonists [3H] nicotine and [3H] acetylcholine …
Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model
JC Dodart, KR Bales, KS Gannon, SJ Greene… - Nature …, 2002 - nature.com
We have previously shown that chronic treatment with the monoclonal antibody m266, which
is specific for amyloid β-peptide (Aβ), increases plasma concentrations of Aβ and reduces …
is specific for amyloid β-peptide (Aβ), increases plasma concentrations of Aβ and reduces …
The revised Piper Fatigue Scale: psychometric evaluation in women with breast cancer.
BF Piper, SL Dibble, MJ Dodd, MC Weiss… - Oncology nursing …, 1998 - europepmc.org
Conclusions The revised version of the PFS consists of 22 items and four subscales:
behavioral/severity (6 items), affective meaning (5 items), sensory (5 items) and …
behavioral/severity (6 items), affective meaning (5 items), sensory (5 items) and …