Methods We conducted a systematic review and meta-analysis of studies reporting
circulating IL-6 in AAA, and new investigations of the association between a common non …

OBJECTIVE Carotid intima-media thickness (CIMT) is a marker of subclinical organ damage
and predicts cardiovascular disease (CVD) events in the general population. It has also …

Objective To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as
an instrument to investigate the causal role of alcohol in cardiovascular disease. Design …

Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and
triglycerides in coronary heart disease (CHD) using multiple instrumental variables for …

Background Low plasma 25-hydroxyvitamin D (25 [OH] D) concentration is associated with
high arterial blood pressure and hypertension risk, but whether this association is causal is …

Background Statin treatment and variants in the gene encoding HMG-CoA reductase are
associated with reductions in both the concentration of LDL cholesterol and the risk of …

Background: The implications of different adiposity measures on cardiovascular disease
etiology remain unclear. In this article, we quantify and contrast causal associations of …

Background and aims Mechanisms for the association between iron stores and risk factors
for diabetes and cardiovascular disease, such as metabolic syndrome (MetS) and its …

OBJECTIVE People with type 2 diabetes are at increased risk of age-related cognitive
decline and dementia. Hypoglycemia is a candidate risk factor, but the direction of …

To identify common variants contributing to normal variation in two specific domains of
cognitive functioning, we conducted a genome-wide association study (GWAS) of executive …