A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
Statistical genetics and bioinformatics Goel Anuj 1 2 … - Nature …, 2011 - nature.com
Genome-wide association studies have identified 11 common variants convincingly
associated with coronary artery disease (CAD),,,,,,, a modest number considering the …
associated with coronary artery disease (CAD),,,,,,, a modest number considering the …
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
JS Kooner, D Saleheen, X Sim, J Sehmi, W Zhang… - Nature …, 2011 - nature.com
We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
P Surendran, F Drenos, R Young, H Warren, JP Cook… - Nature …, 2016 - nature.com
High blood pressure is a major risk factor for cardiovascular disease and premature death.
However, there is limited knowledge on specific causal genes and pathways. To better …
However, there is limited knowledge on specific causal genes and pathways. To better …
Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity
A major goal of biomedicine is to understand the function of every gene in the human
genome. Loss-of-function mutations can disrupt both copies of a given gene in humans and …
genome. Loss-of-function mutations can disrupt both copies of a given gene in humans and …
Causal assessment of serum urate levels in cardiometabolic diseases through a Mendelian randomization study
Background: Although epidemiological studies have reported positive associations between
circulating urate levels and cardiometabolic diseases, causality remains uncertain …
circulating urate levels and cardiometabolic diseases, causality remains uncertain …
[HTML][HTML] Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci
Smoking is a major heritable and modifiable risk factor for many diseases, including cancer,
common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have …
common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have …
Association of the 9p21. 3 locus with risk of first-ever myocardial infarction in Pakistanis: case-control study in South Asia and updated meta-analysis of Europeans
D Saleheen, M Alexander, A Rasheed… - … , and vascular biology, 2010 - Am Heart Assoc
Objective—To examine variants at the 9p21 locus in a case-control study of acute
myocardial infarction (MI) in Pakistanis and to perform an updated meta-analysis of …
myocardial infarction (MI) in Pakistanis and to perform an updated meta-analysis of …
[HTML][HTML] The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia
D Saleheen, M Zaidi, A Rasheed, U Ahmad… - European journal of …, 2009 - Springer
The burden of coronary heart disease (CHD) is increasing at a greater rate in South Asia
than in any other region globally, but there is little direct evidence about its determinants …
than in any other region globally, but there is little direct evidence about its determinants …
Exome chip meta-analysis fine maps causal variants and elucidates the genetic architecture of rare coding variants in smoking and alcohol use
Background Smoking and alcohol use have been associated with common genetic variants
in multiple loci. Rare variants within these loci hold promise in the identification of biological …
in multiple loci. Rare variants within these loci hold promise in the identification of biological …
[HTML][HTML] Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study
S Ahmad, W Zhao, F Renström, A Rasheed… - BMC medical …, 2015 - Springer
Background Multiple genetic variants have been reliably associated with obesity-related
traits in Europeans, but little is known about their associations and interactions with lifestyle …
traits in Europeans, but little is known about their associations and interactions with lifestyle …