A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

Statistical genetics and bioinformatics Goel Anuj 1 2 … - Nature …, 2011 - nature.com
Genome-wide association studies have identified 11 common variants convincingly
associated with coronary artery disease (CAD),,,,,,, a modest number considering the …

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

JS Kooner, D Saleheen, X Sim, J Sehmi, W Zhang… - Nature …, 2011 - nature.com
We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

P Surendran, F Drenos, R Young, H Warren, JP Cook… - Nature …, 2016 - nature.com
High blood pressure is a major risk factor for cardiovascular disease and premature death.
However, there is limited knowledge on specific causal genes and pathways. To better …

Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity

D Saleheen, P Natarajan, IM Armean, W Zhao… - Nature, 2017 - nature.com
A major goal of biomedicine is to understand the function of every gene in the human
genome. Loss-of-function mutations can disrupt both copies of a given gene in humans and …

Causal assessment of serum urate levels in cardiometabolic diseases through a Mendelian randomization study

T Keenan, W Zhao, A Rasheed, WK Ho, R Malik… - Journal of the American …, 2016 - jacc.org
Background: Although epidemiological studies have reported positive associations between
circulating urate levels and cardiometabolic diseases, causality remains uncertain …

[HTML][HTML] Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

AM Erzurumluoglu, M Liu, VE Jackson, DR Barnes… - Molecular …, 2020 - nature.com
Smoking is a major heritable and modifiable risk factor for many diseases, including cancer,
common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have …

Association of the 9p21. 3 locus with risk of first-ever myocardial infarction in Pakistanis: case-control study in South Asia and updated meta-analysis of Europeans

D Saleheen, M Alexander, A Rasheed… - … , and vascular biology, 2010 - Am Heart Assoc
Objective—To examine variants at the 9p21 locus in a case-control study of acute
myocardial infarction (MI) in Pakistanis and to perform an updated meta-analysis of …

[HTML][HTML] The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia

D Saleheen, M Zaidi, A Rasheed, U Ahmad… - European journal of …, 2009 - Springer
The burden of coronary heart disease (CHD) is increasing at a greater rate in South Asia
than in any other region globally, but there is little direct evidence about its determinants …

Exome chip meta-analysis fine maps causal variants and elucidates the genetic architecture of rare coding variants in smoking and alcohol use

DM Brazel, Y Jiang, JM Hughey, V Turcot, X Zhan… - Biological …, 2019 - Elsevier
Background Smoking and alcohol use have been associated with common genetic variants
in multiple loci. Rare variants within these loci hold promise in the identification of biological …

[HTML][HTML] Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study

S Ahmad, W Zhao, F Renström, A Rasheed… - BMC medical …, 2015 - Springer
Background Multiple genetic variants have been reliably associated with obesity-related
traits in Europeans, but little is known about their associations and interactions with lifestyle …