[HTML][HTML] Childhood acute lymphoblastic leukemia: progress through collaboration

CH Pui, JJ Yang, SP Hunger, R Pieters… - Journal of Clinical …, 2015 - ncbi.nlm.nih.gov
Purpose To review the impact of collaborative studies on advances in the biology and
treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. Methods A …

Standardized MRD quantification in European ALL trials: proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18–20 …

M Brüggemann, A Schrauder, T Raff, H Pfeifer… - Leukemia, 2010 - nature.com
Assessment of minimal residual disease (MRD) has acquired a prominent position in
European treatment protocols for patients with acute lymphoblastic leukemia (ALL), on the …

Advances in individual prediction of methotrexate toxicity: a review

K Schmiegelow - British journal of haematology, 2009 - Wiley Online Library
As the cure rates for haematological malignancies have improved, the exploration of the
balance between efficacy and side effects has become a major research target. The …

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update

MV Relling, M Schwab, M Whirl‐Carrillo… - Clinical …, 2019 - Wiley Online Library
Thiopurine methyltransferase (TPMT) activity exhibits a monogenic codominant inheritance
and catabolizes thiopurines. TPMT variant alleles are associated with low enzyme activity …

Reduced ovarian function in long-term survivors of radiation-and chemotherapy-treated childhood cancer

EC Larsen, J Müller, K Schmiegelow… - The Journal of …, 2003 - academic.oup.com
Seventy percent of children with cancer survive. Radiation and chemotherapy may,
however, impair ovarian function. The aim of this population-based study was to achieve a …

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

T Moriyama, R Nishii, V Perez-Andreu, W Yang… - Nature …, 2016 - nature.com
Widely used as anticancer and immunosuppressive agents, thiopurines have narrow
therapeutic indices owing to frequent toxicities, partly explained by TPMT genetic …

Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms

D Otterness, C Szumlanski, L Lennard… - Clinical …, 1997 - Wiley Online Library
Thiopurine methyltransferase (TPMT) catalyzes the S‐methylation of thiopurine drugs. TPMT
activity is regulated by a common genetic polymorphism that is associated with large …

Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia

A Castor, L Nilsson, I Åstrand-Grundström… - Nature medicine, 2005 - nature.com
The cellular targets of primary mutations and malignant transformation remain elusive in
most cancers. Here, we show that clinically and genetically different subtypes of acute …

[HTML][HTML] Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

J Nordlund, CL Bäcklin, P Wahlberg, S Busche… - Genome biology, 2013 - Springer
Background Although aberrant DNA methylation has been observed previously in acute
lymphoblastic leukemia (ALL), the patterns of differential methylation have not been …

[HTML][HTML] Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment

O Hrusak, T Kalina, J Wolf, A Balduzzi… - European Journal of …, 2020 - Elsevier
Introduction Since the beginning of COVID-19 pandemic, it is known that the severe course
of the disease occurs mostly among the elderly, whereas it is rare among children and …