Summary The coronavirus disease 2019 (COVID-19) pandemic is having a profound effect
on all aspects of society, including mental health and physical health. We explore the …

METHOTREXATE, the most widely used antimetabolite in cancer chemotherapy, has an
essential role in the treatment of such diverse diseases as acute lymphocytic leukemia, non …

The mitogen-activated protein kinase (MAPK) superfamily consists of three main protein
kinase families: the extracellular signal-regulated protein kinases (ERKs), the c-Jun N …

Importance SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms
or other health effects occurring after acute infection, termedpostacute sequelae of SARS …

Adriamycin-resistant (AdrR) human breast cancer cells have been selected which exhibit
cross-resistance to a wide range of anti-cancer drugs. This multidrug-resistant phenotype is …

Background Breast-conservation therapy for early-stage breast cancer is now an accepted
treatment, but there is still controversy about its comparability with mastectomy. Between …

Cyclophosphamide (Cy) is a potent immunosuppressive agent that is selectively toxic to
lymphocytes proliferating in response to recent antigen stimulation. In animal models, both …

The breast cancer tumor-suppressor gene, BRCA1, encodes a protein with a BRCT domain—
a motif that is found in many proteins that are implicated in DNA damage response and in …

Pannexins are mammalian orthologs of the invertebrate gap junction proteins innexins and
thus have been proposed to play a role in gap junctional intercellular communication …

Progression of pulmonary hypertension is associated with increased serine elastase activity
and the proteinase-dependent deposition of the extracellular matrix smooth muscle cell …