Heme and iron metabolism are of considerable interest and importance in normal brain
function as well as in neurodegeneration and neuropathologically following traumatic injury …

Objective: Delayed cerebral vasospasm has long been recognized as an important cause of
poor outcome after an otherwise successful treatment of a ruptured intracranial aneurysm …

Opinion statement Patients with renal cell cancer (RCC) develop metastatic spread in
approximately 33% of cases. The clinical management of patients with metastatic RCC is …

Background An improvement in overall survival among patients with metastatic melanoma
has been an elusive goal. In this phase 3 study, ipilimumab—which blocks cytotoxic T …

Defective dendritic cell (DC) function caused by abnormal differentiation of these cells is an
important mechanism of tumor escape from immune system control. Previously, we have …

Background Brain metastases commonly develop in patients with melanoma and are a
frequent cause of death of patients with this disease. Ipilimumab improves survival in …

CRISPR-Cas-mediated genome editing relies on guide RNAs that direct site-specific DNA
cleavage facilitated by the Cas endonuclease. Here we report that chemical alterations to …

Purpose The Cytokine Working Group conducted a randomized phase III trial to determine
the value of outpatient interleukin-2 (IL-2) and interferon alfa-2b (IFN) relative to high-dose …

Defective dendritic cell (DC) function has been described previously in cancer patients and
tumor-bearing mice. It can be an important factor in the escape of tumors from immune …

Background The relative efficacy of the addition of induction chemotherapy to
chemoradiotherapy compared with chemoradiotherapy alone for patients with head and …