Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis
LF Eichenfield, WL Tom, SL Chamlin… - Journal of the American …, 2014 - Elsevier
Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that affects up to 25% of
children and 2% to 3% of adults. This guideline addresses important clinical questions that …
children and 2% to 3% of adults. This guideline addresses important clinical questions that …
Acne vulgaris
HC Williams, RP Dellavalle, S Garner - The Lancet, 2012 - thelancet.com
Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-
induced increased sebum production, altered keratinisation, inflammation, and bacterial …
induced increased sebum production, altered keratinisation, inflammation, and bacterial …
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
…, L Georgieva, I Nikolov, N Norton, H Williams… - Nature, 2009 - nature.com
Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%,. We …
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%,. We …
The global burden of cancer 2013
C Fitzmaurice, D Dicker, A Pain, H Hamavid… - JAMA …, 2015 - jamanetwork.com
Importance Cancer is among the leading causes of death worldwide. Current estimates of
cancer burden in individual countries and regions are necessary to inform local cancer …
cancer burden in individual countries and regions are necessary to inform local cancer …
[HTML][HTML] Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Background Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The
multicenter, double-blind, placebo-and celecoxib-controlled Glucosamine/chondroitin …
multicenter, double-blind, placebo-and celecoxib-controlled Glucosamine/chondroitin …
[BOOK][B] Model building in mathematical programming
HP Williams - 2013 - books.google.com
The 5th edition of Model Building in Mathematical Programming discusses the general
principles of model building in mathematical programming and demonstrates how they can …
principles of model building in mathematical programming and demonstrates how they can …
[HTML][HTML] A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults
MN Oxman, MJ Levin, GR Johnson… - … England Journal of …, 2005 - Mass Medical Soc
Background The incidence and severity of herpes zoster and postherpetic neuralgia
increase with age in association with a progressive decline in cell-mediated immunity to …
increase with age in association with a progressive decline in cell-mediated immunity to …
Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003
SGO Johansson, T Bieber, R Dahl… - Journal of allergy and …, 2004 - Elsevier
The nomenclature proposed in the October 2003 report of the Nomenclature Review
Committee of the World Allergy Organization is an update of the European Academy of …
Committee of the World Allergy Organization is an update of the European Academy of …
[BOOK][B] The grammar book: An ESL/EFL teacher's course
M Celce-Murcia, D Larsen-Freeman, HA Williams - 1983 - tesl-ej.org
The second edition of Celce-Murcia and Larsen-Freeman's amazing tome, The Grammar
Book, is even better than the first. The subject matter is expanded, the prose is tighter, the …
Book, is even better than the first. The subject matter is expanded, the prose is tighter, the …