Why blockade of the renin–angiotensin system reduces the incidence of new-onset diabetes
Recent trials have suggested that inhibitors of the renin–angiotensin system (RAS), such as
angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers …
angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers …
Metabolic benefits of dietary prebiotics in human subjects: a systematic review of randomised controlled trials
Complex relationships exist between the gut microflora and their human hosts. Emerging
evidence suggests that bacterial dysbiosis within the colon may be involved in the …
evidence suggests that bacterial dysbiosis within the colon may be involved in the …
Quarter-dose quadruple combination therapy for initial treatment of hypertension: placebo-controlled, crossover, randomised trial and systematic review
CK Chow, J Thakkar, A Bennett, G Hillis, M Burke… - The Lancet, 2017 - thelancet.com
Background Globally, most patients with hypertension are treated with monotherapy, and
control rates are poor because monotherapy only reduces blood pressure by around 9/5 mm …
control rates are poor because monotherapy only reduces blood pressure by around 9/5 mm …
[HTML][HTML] A comparison of outcomes with angiotensin-converting–enzyme inhibitors and diuretics for hypertension in the elderly
Background Treatment of hypertension with diuretics, beta-blockers, or both leads to
improved outcomes. It has been postulated that agents that inhibit the renin–angiotensin …
improved outcomes. It has been postulated that agents that inhibit the renin–angiotensin …
[HTML][HTML] Effect of aspirin on cardiovascular events and bleeding in the healthy elderly
Background Aspirin is a well-established therapy for the secondary prevention of
cardiovascular events. However, its role in the primary prevention of cardiovascular disease …
cardiovascular events. However, its role in the primary prevention of cardiovascular disease …
[HTML][HTML] Effect of aspirin on all-cause mortality in the healthy elderly
Background In the primary analysis of the Aspirin in Reducing Events in the Elderly
(ASPREE) trial, now published in the Journal, we report that the daily use of aspirin did not …
(ASPREE) trial, now published in the Journal, we report that the daily use of aspirin did not …
[HTML][HTML] Cholesterol lowering in intermediate-risk persons without cardiovascular disease
Background Previous trials have shown that the use of statins to lower cholesterol reduces
the risk of cardiovascular events among persons without cardiovascular disease. Those …
the risk of cardiovascular events among persons without cardiovascular disease. Those …
[HTML][HTML] Blood-pressure lowering in intermediate-risk persons without cardiovascular disease
Background Antihypertensive therapy reduces the risk of cardiovascular events among high-
risk persons and among those with a systolic blood pressure of 160 mm Hg or higher, but its …
risk persons and among those with a systolic blood pressure of 160 mm Hg or higher, but its …
Pet ownership and risk factors for cardiovascular disease
WP Anderson, CM Reid… - Medical journal of …, 1992 - Wiley Online Library
Objective: To compare risk factors for cardiovascular disease in pet owners and non‐
owners. Design and patients: Accepted risk factors for cardiovascular disease were …
owners. Design and patients: Accepted risk factors for cardiovascular disease were …
2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: the ADAPT trial
Objectives: The purpose of this study was to determine whether a new accelerated
diagnostic protocol (ADP) for possible cardiac chest pain could identify low-risk patients …
diagnostic protocol (ADP) for possible cardiac chest pain could identify low-risk patients …