Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: an international consensus statement …
Beckwith-Wiedemann syndrome (BWS), a human genomic imprinting disorder, is
characterized by phenotypic variability that might include overgrowth, macroglossia …
characterized by phenotypic variability that might include overgrowth, macroglossia …
1, 2-Diacetals: a new opportunity for organic synthesis
SV Ley, DK Baeschlin, DJ Dixon, AC Foster… - Chemical …, 2001 - ACS Publications
While 1, 2-diacetals have been known in the literature since 1938, 1 their specific
application in organic synthesis has been recognized only recently. It seems remarkable to …
application in organic synthesis has been recognized only recently. It seems remarkable to …
[HTML][HTML] Clinical and molecular diagnosis, screening and management of Beckwith–Wiedemann syndrome: an international consensus statement
Abstract Beckwith–Wiedemann syndrome (BWS), a human genomic imprinting disorder, is
characterized by phenotypic variability that might include overgrowth, macroglossia …
characterized by phenotypic variability that might include overgrowth, macroglossia …
Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders
By analyzing the whole-exome sequences of 4,264 schizophrenia cases, 9,343 controls and
1,077 trios, we identified a genome-wide significant association between rare loss-of …
1,077 trios, we identified a genome-wide significant association between rare loss-of …
Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: a multicenter study
CC Bell, ACA Dankers, VM Lauschke… - Toxicological …, 2018 - academic.oup.com
Primary human hepatocytes (PHHs) are commonly used for in vitro studies of drug-induced
liver injury. However, when cultured as 2D monolayers, PHH lose crucial hepatic functions …
liver injury. However, when cultured as 2D monolayers, PHH lose crucial hepatic functions …
[HTML][HTML] Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury
WR Proctor, AJ Foster, J Vogt, C Summers… - Archives of …, 2017 - Springer
Drug-induced liver injury (DILI) continues to be a major source of clinical attrition,
precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need …
precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need …
Cortisol in mother's milk across lactation reflects maternal life history and predicts infant temperament
K Hinde, AL Skibiel, AB Foster, L Del Rosso… - Behavioral …, 2015 - academic.oup.com
The maternal environment exerts important influences on offspring mass/growth,
metabolism, reproduction, neurobiology, immune function, and behavior among birds …
metabolism, reproduction, neurobiology, immune function, and behavior among birds …
In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs
RA Thompson, EM Isin, Y Li, L Weidolf… - Chemical research in …, 2012 - ACS Publications
Idiosyncratic adverse drug reactions (IADRs) in humans can result in a broad range of
clinically significant toxicities leading to attrition during drug development as well as …
clinically significant toxicities leading to attrition during drug development as well as …
[HTML][HTML] Poly (A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita
Dyskeratosis congenita (DC) and related syndromes are inherited, life-threatening bone
marrow (BM) failure disorders, and approximately 40% of cases are currently …
marrow (BM) failure disorders, and approximately 40% of cases are currently …
The broiler chicken as a signal of a human reconfigured biosphere
Changing patterns of human resource use and food consumption have profoundly impacted
the Earth's biosphere. Until now, no individual taxa have been suggested as distinct and …
the Earth's biosphere. Until now, no individual taxa have been suggested as distinct and …