Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding
Transcription factors (TFs) direct gene expression by binding to DNA regulatory regions. To
explore the evolution of gene regulation, we used chromatin immunoprecipitation with high …
explore the evolution of gene regulation, we used chromatin immunoprecipitation with high …
[HTML][HTML] Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: an international registry study
Background & Aims Chronic liver disease (CLD) and cirrhosis are associated with immune
dysregulation, leading to concerns that affected patients may be at risk of adverse outcomes …
dysregulation, leading to concerns that affected patients may be at risk of adverse outcomes …
[HTML][HTML] Supportive and palliative care in people with cirrhosis: international systematic review of the perspective of patients, family members and health professionals
JTS Low, G Rohde, K Pittordou, B Candy, S Davis… - Journal of …, 2018 - Elsevier
Background & Aims People with cirrhosis have unmet needs, which could benefit from a
palliative care approach. Developing effective services needs to be based on evidence from …
palliative care approach. Developing effective services needs to be based on evidence from …
[HTML][HTML] Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages
CTCF-binding locations represent regulatory sequences that are highly constrained over the
course of evolution. To gain insight into how these DNA elements are conserved and spread …
course of evolution. To gain insight into how these DNA elements are conserved and spread …
High mortality rates for SARS-CoV-2 infection in patients with pre-existing chronic liver disease and cirrhosis: preliminary results from an international registry
[1] Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality
of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet …
of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet …
[HTML][HTML] Outcomes following SARS-CoV-2 infection in liver transplant recipients: an international registry study
Background Despite concerns that patients with liver transplants might be at increased risk
of adverse outcomes from COVID-19 because of coexisting comorbidities and use of …
of adverse outcomes from COVID-19 because of coexisting comorbidities and use of …
[PDF][PDF] Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T‐regulatory cells
E Unitt, SM Rushbrook, A Marshall, S Davies… - …, 2005 - Wiley Online Library
Hepatocellular carcinoma (HCC) has a poor prognosis with limited therapeutic options. We
propose that local immune responses in patients with HCC are held in check by tumor …
propose that local immune responses in patients with HCC are held in check by tumor …
[PDF][PDF] Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation
The expansion of repressive epigenetic marks has been implicated in heterochromatin
formation during embryonic development, but the general applicability of this mechanism is …
formation during embryonic development, but the general applicability of this mechanism is …
Tumour lymphocytic infiltrate and recurrence of hepatocellular carcinoma following liver transplantation
E Unitt, A Marshall, W Gelson, SM Rushbrook… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: Liver transplantation is an effective treatment for highly selected
patients with hepatocellular carcinoma (HCC), but tumour recurrence remains an important …
patients with hepatocellular carcinoma (HCC), but tumour recurrence remains an important …
Relation between hepatocyte G1 arrest, impaired hepatic regeneration, and fibrosis in chronic hepatitis C virus infection
A Marshall, S Rushbrook, SE Davies, LS Morris… - Gastroenterology, 2005 - Elsevier
Backgrounds & Aims: An increased risk of hepatitis C virus (HCV)-related cirrhosis is
associated with hepatic steatosis, older age, and high alcohol consumption, which could be …
associated with hepatic steatosis, older age, and high alcohol consumption, which could be …