Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC

Lancet Oncol. 2012 Feb;13(2):e58-68. doi: 10.1016/S1470-2045(12)70040-2.

Abstract

Here we provide the updated version of the guidelines of the European Association for Palliative Care (EAPC) on the use of opioids for the treatment of cancer pain. The update was undertaken by the European Palliative Care Research Collaborative. Previous EAPC guidelines were reviewed and compared with other currently available guidelines, and consensus recommendations were created by formal international expert panel. The content of the guidelines was defined according to several topics, each of which was assigned to collaborators who developed systematic literature reviews with a common methodology. The recommendations were developed by a writing committee that combined the evidence derived from the systematic reviews with the panellists' evaluations in a co-authored process, and were endorsed by the EAPC Board of Directors. The guidelines are presented as a list of 16 evidence-based recommendations developed according to the Grading of Recommendations Assessment, Development and Evaluation system.

Publication types

  • Practice Guideline
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Analgesics, Opioid / administration & dosage*
  • Analgesics, Opioid / adverse effects
  • Analgesics, Opioid / therapeutic use*
  • Central Nervous System Diseases / chemically induced
  • Central Nervous System Diseases / drug therapy
  • Chronic Pain / drug therapy*
  • Constipation / chemically induced
  • Constipation / drug therapy
  • Evidence-Based Practice
  • Humans
  • Neoplasms / complications
  • Neoplasms / physiopathology*
  • Neuralgia / drug therapy
  • Palliative Care*
  • Renal Insufficiency / complications
  • Vomiting / chemically induced
  • Vomiting / drug therapy

Substances

  • Analgesics, Opioid