Measures of aggressiveness of end-of-life care in patients with acute myeloid leukaemia receiving ePSC or late referral PC
| ePSC | Late PC | RD, % (95% CI) | P value | |||
| n/n | % | n/n | % | |||
| Chemotherapy | ||||||
| Within 90 days of death | 19/75 | 25.3 | 17/36 | 47.2 | −21.9 (−40.9 to −2.8) | 0.0211 |
| Within 30 days of death | 7/75 | 9.3 | 10/36 | 27.8 | −18.4 (−34.5 to −2.4) | 0.0115 |
| Within 14 days of death* | 2/75 | 2.7 | 5/36 | 13.9 | −11.2 (−23.1 to 0.65) | 0.0228 |
| ICU admission | ||||||
| Within 30 days of death* | 0/75 | 0 | 5/34 | 14.7 | −14.7 (−26.6 to −2.8) | 0.0007 |
| Intubation | ||||||
| Within 30 days of death* | 0/75 | 0 | 2/33 | 6.1 | −6.1 (−14.2 to 2.1) | 0.0314 |
| CPR | ||||||
| Within 30 days of death* | 0/75 | 0 | 0/40 | NE | NE | N.E. |
| Access to ED | ||||||
| ≥2 within 30 days of death* | 3/75 | 4 | 8/34 | 23.5 | −19.5 (−34.5 to −4.6) | 0.001 |
| Within 30 days of death | 29/75 | 38.7 | 18/34 | 52.9 | −14.3 (−34.3 to 5.8) | 0.1633 |
| Within 14 days of death | 20/75 | 26.7 | 15/34 | 44.1 | −17.5 (−36.9 to 2.0) | 0.0706 |
| Hospitalisation | ||||||
| ≥2 within 30 days of death* | 3/75 | 4 | 4/34 | 11.8 | −7.8 (−19.5 to 3.9) | 0.1255 |
| Home/hospice care service | ||||||
| Inpatient hospice service | 11/75 | 14.7 | 3/37 | 8.11 | 6.6 (−5.3 to 18.5) | 0.3236 |
| Hospice length of stay >7 days* | 8/75 | 10.7 | 2/40 | 5 | 5.7 (−4.1 to 15.4) | 0.3043 |
| Home-care service | 48/75 | 64 | 12/40 | 30 | 34 (16.1 to 51.9) | 0.0005 |
| Opiate use | ||||||
| Within 30 days of death | 44/75 | 58.7 | 15/37 | 40.5 | 18.1 (−1.2 to 37.5) | 0.0707 |
| Place of death | ||||||
| Hospice or home | 38/75 | 50.7 | 11/36 | 30.6 | 20.1 (1.3 to 38.9) | 0.0458 |
| Hospital | 33/75 | 44 | 25/36 | 69.4 | −25.4 (−44.2 to −6.7) | 0.012 |
| Acute facility* | 4/75 | 5.3 | 11/35 | 31.4 | −26.1 (−42.3 to −9.9) | 0.002 |
| No red cell transfusion | ||||||
| Within 7 days of death* | 37/75 | 49.3 | 9/32 | 28.12 | 22.5 (3.3 to 41.8) | 0.0315 |
| No platelet transfusion | ||||||
| Within 7 days of death* | 31/75 | 41.3 | 9/32 | 28.16 | 13.2 (−5.9 to 32.4) | 0.1960 |
*Indicators of aggressiveness of care at the end of life.16 32
CPR, cardiopulmonary resuscitation; ED, emergency department; ePSC, early palliative supportive care; ICU, intensive care unit; NE, not evaluable; late PC, late referral to palliative care; RD, risk difference.