General condition and clinical characteristics of patients
| General condition | Whole (n=62） | SG (n=32） | NSG (n=30) | P value |
| Age (mean±SD） | 74.29±12.43 | 77.88±12.04 | 70.47±11.85 | 0.767 |
| Male (%） | 47 (75.8) | 25 (40.3%） | 22 (35.5) | 0.770 |
| Female (%） | 15 (24.2) | 7 (11.3%) | 8 (12.9) | 0.710 |
| Dead in 28 days, n (%） | 15 (24.2) | 11 (17.7) | 4 (6.5) | 0.049* |
| Time of onset sepsis (day） | 1.92±0.58 | – | – | |
| Infection site, n (%） | ||||
| Lung infection | 49 (79.0) | 24 (38.7) | 25 (40.3) | 0.448 |
| Abdominal infection | 6 (9.7) | 4 (6.5) | 2 (3.2) | 0.248 |
| Urinary tract infections | 5 (8.1) | 2 (3.2) | 3 (4.9) | 0.410 |
| Skin and soft tissue infections | 1 (1.6) | 0 | 1 (1.6) | – |
| Unknown site of infection | 1 (1.6) | 1 (1.6) | 0 | – |
| Admission vital signs | ||||
| Systolic BP mm Hg (mean±SD） | 128.69±15.18 | 129.84±15.60 | 127.47±14.88 | 0.614 |
| Diastolic BP mm Hg (mean±SD） | 72.00±11.33 | 73±12.23 | 70.93±10.39 | 0.596 |
| MAP mm Hg (mean±SD） | 90.90±10.84 | 91.95±11.43 | 89.78±10.25 | 0.289 |
| Heart rate, bmp (mean±SD） | 99.03±20.31 | 101.13±22.19 | 96.80±18.20 | 0.775 |
| BMI (mean±SD） | 23.19±3.95 | 22.92±4.22 | 23.48±3.68 | 0.404 |
| Laboratory indicators | ||||
| Platelets (×109） | 218.21±105.40 | 199.72±108.56 | 237.93±99.96 | 0.937 |
| Haemoglobin (g/L） | 118.31±28.81 | 115.91±26.29 | 120.87±23.30 | 0.482 |
| PCT (ng/ml） | 6.83±21.79 | 10.20±27.04 | 3.11±13.43 | 0.034* |
| CRP (mg/L） | 35.75±124.02 | 67.25±174.84 | 7.63±26.66 | 0.001* |
| Bundle (g/L) | 35.18±6.41 | 34.36±5.58 | 36.05±7.18 | 0.104 |
| D-dimer (mg/L） | 4.60±7.51 | 5.64±8.15 | 3.44±6.68 | 0.366 |
| Blood lactic acid | 1.91±1.96 | 2.43±2.58 | 1.36±0.54 | 0.000* |
| Alkali Surplus | −0.24±8.06 | −1.14±8.58 | 0.72±0.01 | 0.110 |
| Clinical scoring | ||||
| APACHE II (mean±SD） | 12.98±6.16 | 14.53±6.68 | 11.33±5.16 | 0.400 |
| SOFA (mean±SD） | 2.79±2.40 | 3.28±2.93 | 2.27±1.55 | 0.120 |
| T3 (mean±SD） | 0.63±0.86 | 0.51±0.22 | 0.79±1.28 | 0.087 |
| T4 (mean±SD） | 5.87±2.40 | 5.93±2.38 | 5.79±2.47 | 0.900 |
| FT3 (mean±SD） | 1.88±0.55 | 1.81±0.55 | 1.96±0.55 | 0.964 |
| FT4 (mean±SD） | 1.13±0.39 | 1.09±0.29 | 1.18±0.50 | 0.372 |
| FT3/T3 (mean±SD） | 4.24±2.48 | 4.37±2.97 | 4.09±1.70 | 0.395 |
| FT4/T4 (mean±SD） | 0.22±0.19 | 0.20±0.05 | 0.25±0.28 | 0.076 |
| T3/T4 (mean±SD） | 0.15±0.45 | 0.09±0.04 | 0.23±0.68 | 0.038* |
| TSH (mean±SD） | 2.54±6.77 | 1.19±1.02 | 4.29±10.03 | 0.002* |
*Comparison of sepsis group and non-sepsis group, p<0.05.
APACHEII, Acute Physiology and Chronic Health Evaluation II; BMI, body mass index; BP, blood pressure; CRP, C reactive protein; MAP, mean arterial pressure; NSG, non-sepsis group; PCT, procalcitonin; SG, sepsis group; SOFA, Sequential Organ Failure Assessment; TSH, thyroid-stimulating hormone.