Table 5

Changes in cognitive function (Gagnon cognitive test) at day 6, according to initial fatigue level‡

Questions (Q)RankModerate fatigue
Mean (SD)
Severe fatigue
Mean (SD)
PlaceboMethylphenidatePlaceboMethylphenidate
Repeating a list of words
 Immediate repetition (Q1)(0–5)−0.4 (0.6)0.0 (0.9)−0.3 (0.7)−0.2 (1.0)
 Deferred repeat 1 (Q4) *(0–5)+0.3 (1.9)0.0 (2.1)+0.5 (2.3)0.6 (1.4)
 Deferred repeat 2 (Q4)* (Q7)†(0–5)+0.4 (1.8)0.2 (2.1)+0.3 (1.7)0.4 (1.6)
Repeating progressive series of digits
 Forward (Q2)(0–84)+2.2 (17.5)6.3 (17.6)+1.5 (8.5)1.9 (16.9)
 Backward (Q3)(0–70)−0.3 (7.3)0.5 (9.1)−0.1 (6.0)2.0 (10.0)
 Accuracy when copying figure (Q5)Embedded Image (0–10)0.0 (1.5)0.0 (2.4)−0.2 (2.0)−0.1 (2.1)
 Write a given phrase (Q6)(0–4)+0.1 (0.4)0.3 (0.7)−0.8 (1.9)0.4 (0.7)
  • *Alternating questions 2 and 3.

  • †Alternating questions 5 and 6.

  • ‡No comparison between placebo and methylphenidate is statistically significant.