G-CSF attribute | As primary prophylaxis | As secondary prophylaxis | ||
Coefficient (error type) | P value | Coefficient (error type) | P value | |
Efficacy | ||||
Risk of febrile neutropenia with prophylaxis | 0.039 (0.016) | 0.015 | 0.094 (0.017) | <0.001 |
G-CSF characteristic | ||||
Biosimilar | 0.145 (0.018) | <0.001 | 0.110 (0.018) | <0.001 |
G-CSF administration and cost | ||||
Cost per injection, including cost of nurse (euros) | 0.114 (0.010) | <0.001 | 0.106 (0.011) | <0.001 |
Number of injections per chemotherapy cycle | 0.212 (0.010) | <0.001 | 0.137 (0.011) | <0.001 |
Tolerance | ||||
Pain at the injection site | 0.077 (0.016) | <0.001 | 0.046 (0.017) | 0.005 |
Bone pain present | −0.040 (0.016) | 0.012 | −0.072 (0.017) | <0.001 |
Fever/influenza syndrome present | −0.037 (0.016) | 0.023 | −0.051 (0.017) | 0.002 |
G-CSF, granulocyte colony-stimulating factors.