OS subgroup | Studies (n) | Pooled HR (95% CI) | Meta-regression p value | Heterogeneity | ||
Fixed | Random | I2 (%) | P value | |||
Year | 0.43 | |||||
Before 2010 | 7 | 2.08 (1.62 to 2.66) | 1.87 (1.20 to 2.92) | 67 | 0.006 | |
After 2010 | 10 | 1.30 (1.17 to 1.44) | 1.53 (1.21 to 1.94) | 68 | 0.0009 | |
Region | 0.004 (<0.00001) | |||||
Asia | 3 | 2.06 (1.57 to 2.70) | 2.06 (1.57 to 2.70) | 0 | 0.38 | |
Europe | 10 | 1.92 (1.59 to 2.31) | 1.92 (1.48 to 2.49) | 42 | 0.08 | |
North America | 3 | 1.22 (1.05 to 1.42) | 2.60 (0.86 to 7.84) | 90 | <0.00001 | |
South America | 2 | 1.43 (1.29 to 1.57) | 0.99 (0.71 to 1.38) | 21 | 0.26 | |
Sample size | 0.45 | |||||
More than 300 | 5 | 1.33 (1.17 to 1.51) | 1.57 (1.10 to 2.24) | 80 | 0.0005 | |
Less than 300 | 13 | 1.57 (1.35 to 1.83) | 1.90 (1.35 to 2.66) | 74 | <0.00001 | |
Cut-off | 0.005 (<0.0001) | |||||
>10% | 12 | 1.74 (1.52 to 2.00) | 2.12 (1.56 to 2.88) | 76 | <0.00001 | |
Other value | 6 | 1.16 (1.01 to 1.33) | 1.21 (0.96 to 1.54) | 28 | 0.23 | |
Survival analysis | >0.99 | |||||
Univariate | 9 | 1.56 (1.34 to 1.82) | 1.78 (1.24 to 2.54) | 73 | 0.00002 | |
Multivariate | 9 | 1.35 (1.19 to 1.53) | 1.78 (1.25 to 2.52) | 78 | <0.0001 | |
Follow-up time | 0.4 | |||||
5 years | 3 | 2.16 (1.47 to 3.16) | 2.33 (1.14 to 4.75) | 70 | 0.04 | |
10 years | 15 | 1.39 (1.25 to 1.53) | 1.69 (1.32 to 2.16) | 75 | <0.0001 | |
Quality score | 0.94 | |||||
>72 | 10 | 1.42 (1.26 to 1.60) | 1.77 (1.32 to 2.37) | 71 | 0.0003 | |
<72 | 8 | 1.44 (1.29 to 1.70) | 1.80 (1.15 to 2.81) | 81 | <0.00001 |
OS, overall survival.