Table 5

Subgroup meta-analysis for OS

OS subgroupStudies (n)Pooled HR (95% CI)Meta-regression p valueHeterogeneity
FixedRandomI2 (%)P value
Year0.43
Before 201072.08 (1.62 to 2.66)1.87 (1.20 to 2.92)670.006
After 2010101.30 (1.17 to 1.44)1.53 (1.21 to 1.94)680.0009
Region0.004 (<0.00001)
Asia32.06 (1.57 to 2.70)2.06 (1.57 to 2.70)00.38
Europe101.92 (1.59 to 2.31)1.92 (1.48 to 2.49)420.08
North America31.22 (1.05 to 1.42)2.60 (0.86 to 7.84)90<0.00001
South America21.43 (1.29 to 1.57)0.99 (0.71 to 1.38)210.26
Sample size0.45
More than 30051.33 (1.17 to 1.51)1.57 (1.10 to 2.24)800.0005
Less than 300131.57 (1.35 to 1.83)1.90 (1.35 to 2.66)74<0.00001
Cut-off0.005 (<0.0001)
>10%121.74 (1.52 to 2.00)2.12 (1.56 to 2.88)76<0.00001
Other value61.16 (1.01 to 1.33)1.21 (0.96 to 1.54)280.23
Survival analysis>0.99
Univariate91.56 (1.34 to 1.82)1.78 (1.24 to 2.54)730.00002
Multivariate91.35 (1.19 to 1.53)1.78 (1.25 to 2.52)78<0.0001
Follow-up time0.4
5 years32.16 (1.47 to 3.16)2.33 (1.14 to 4.75)700.04
10 years151.39 (1.25 to 1.53)1.69 (1.32 to 2.16)75<0.0001
Quality score0.94
>72101.42 (1.26 to 1.60)1.77 (1.32 to 2.37)710.0003
<7281.44 (1.29 to 1.70)1.80 (1.15 to 2.81)81<0.00001
  • OS, overall survival.