Table 28

Risperidone orodispersible

Risperidone orodispersible
What is it?Anti-psychotic
Mechanism of action‘Risperidone is a dopamine D2, 5-HT2A, alpha1-adrenoceptor, and histamine-1 receptor antagonist’ (British National Formulary).
Starting dose0.5 mg OD (can be increased to BD if needed)
Time to effectHours to days
FormulationOrodispersible tablet
IndicationDelirium, terminal agitation
Common adverse effects‘Anaemia; anxiety; appetite abnormal; asthenia; chest discomfort; conjunctivitis; cough; depression; diarrhoea; dyspnoea; epistaxis; fall; fever; gastrointestinal discomfort; headache; hyperglycaemia; hypertension; increased risk of infection; joint disorders; laryngeal pain; muscle spasms; nasal congestion; nausea; oedema; oral disorders; pain; sexual dysfunction; skin reactions; sleep disorders; urinary disorders; vision disorders; weight decreased’16
ContraindicationsHypersensitivity to the active substance or to any of the excipients
Caution‘Avoid in Acute porphyrias; cataract surgery (risk of intra-operative floppy iris syndrome); dehydration; dementia with Lewy bodies; prolactin-dependent tumours’16
Seizure, Parkinsonism, renal and liver failure, old age16
Licencing‘Off label’ use of a licensed formulation
BenefitsOrodispersible alternative anti-psychotic
RisksNarrower spectrum of action than olanzapine, currently not widely use outside of psychiatry
Cost£18.28 for 28×500 μg orodispersible tablets