Hyoscine hydrobromide chewable
| Hyoscine hydrobromide chewable | |
| What is it? | Antimuscarinic |
| Mechanism of action | Antisecretory with smooth muscle relaxant properties |
| Starting dose | 150 μg 4 hourly prn |
| Time to onset of effect | 10–15 min17 |
| Formulation | Chewable tablets |
| Indication | Sialorrhoea Drooling Smooth muscle spasm Paraneoplastic fevers and sweating |
| Common Adverse Effects | Constipation; dizziness; drowsiness; dry mouth; dyspepsia; flushing; headache; nausea; palpitations; skin reactions; tachycardia; urinary disorders; vision disorders; vomiting16 |
| Contraindications | Tachycardia >100 Cardiac conduction disorders16 |
| Caution | Crosses blood brain barrier so may cause sedation Elderly Renal and hepatic impairment May prefer to use transdermal patch |
| Licence | ‘off label’ use of a licensed product |
| Benefits | Chewable alternative |
| Risks | Aspiration |
| Cost | £1.67 for 12×150 mg Kwells £1.99 for 12×150 μg Joy-Rides tablet |