ESAS scale | Control group n=76 Mean score±SD (median) | Treatment group n=104 Mean score±SD (median) | p Values* | ||
Initial visit | 6-week visit | Initial visit | 6-week visit | ||
Pain | 5.1±3.4 (6) | 4.8±3.9 (5) | 5.2±2.9 (5) | 4.4±3.1 (4.5) | p1=0.87 p2<0.003 p3=0.50 p4=0.17 |
Fatigue | 6.5±2.8 (6.5) | 6.4±2.4 (7) | 6.5±2.4 (7) | 5.7±2.4 (6) | p1=0.79 p2=0.007 p3=0.56 p4=0.15 |
Nausea | 3.1±3.4 (2) | 2.7±3.5 (0) | 3.3±3.2 (2) | 2.6±3.0 (1) | p1=0.46 p2=0.035 p3=0.36 p4=0.39 |
Depression | 3.8±3.6 (3.5) | 3.3±3.3 (3) | 4.1±3.3 (4) | 2.9±2.9 (2) | p1=0.38 p2<0.000 p3=0.19 p4=0.16 |
Anxiety | 4.1±3.5 (4) | 4.1±3.5 (4.5) | 4.8±3.5 (5) | 3.4±3.2 (2.5) | p1=0.13 p2<0.000 p3=0.94 p4=0.004 |
Drowsiness | 5.4±3.3 (6) | 5.2±3.1 (5) | 5.3±2.9 (6) | 4.5±2.9 (5) | p1=0.76 p2=0.014 p3=0.99 p4=0.07 |
Shortness of breath | 1.8±2.7 (0) | 2.2±3.0 (0) | 2.3±2.8 (1) | 2.1±3.1 (0) | p1=0.065 p2=0.19 p3=0.28 p4=0.08 |
Appetite | 4.4±3.4 (5) | 4.8±3.7 (5) | 5.1±3.1 (5) | 4.5±3 (5) | p1=0.27 p2=0.077 p3=0.52 p4=0.13 |
Sleep | 6.1±2.1 (6) | 5.8±2.9 (6) | 6.6±2.3 (7) | 5.2±2.7 (5) | p1=0.12 p2<0.000 p3=0.92 p4=0.008 |
Feeling of well-being | 6.6±2.0 (7) | 6.4±2.3 (7) | 6.5±2.3 (6) | 5.3±2.5 (5) | p1=0.77 p2<0.000 p3=0.59 p4=0.007 |
*p Values are presented concerning the following comparisons between the control and treatment groups: p1=compared treatment and control group scores in initial visit (baseline scores); p2=within-treatment group score changes from initial to 6-week visit; p3=within-control group score changes from initial to 6-week visit; p4=between treatment and control group changes from initial to 6-week visit.