Table 1

Reports of studies on chemotherapy during the last 30 days of life (DOL)

			% Receiving chemotherapy during
Study	Patients, N	Type of cancer	Inclusion criteria	Last 30 DOL	Last 14 DOL
Rautakorpi et al25	38 982	All	Any	16	7.2
Falchook et al32	12 765	Lung	Patients<65 years	12.6
Ersek et al42	847	NSCLC	Any	30.6
Wright et al14	1146	All	Any		6.5
Bekelman et al49	389 073	All	USA	10.6
			The Netherlands	10.6
			Belgium	12.7
			Canada	8.8
			UK	NR
			Germany	10.5
			Norway	4.8
Sano and Fushimi45	26 012	All	Palliative care consultation		1.7
Sano and Fushimi45	26 012	All	SOC		4.0
Parekh et al51	242	NSCLC	2009–10 Prepalliative care		17.0
Parekh et al51	242	NSCLC	2003–14 Postpalliative care		7.0
Pacetti et al39	2164	All	Any	24.3
Wang et al52	82 242	All	2005		4.4
Wang et al52	82 242	All	2009		4.0
Choi et al30	263	All	2002	14.0	3.5
Choi et al30	263	All	2012	42.7	23.8
Cheung et al31	107 253	All	Any		3.6
Lee et al38	2345	All	2000	25.7
			2005	32.7
			2010	44.2
Kok et al27	266	NSCLC	2008–2009		5.0
Kok et al27	266	NSCLC	2011–2012		1.0
Zhang et al63	118	NSCLC	Any	27
Adam et al33	120	All	Any	11.7	7.6
Sesé et al35	94	Lung	Any	55	22
Amano et al58	266	All	Early palliative care	17
Amano et al58	266	All	SOC	23
Greer et al29	151	NSCLC	SOC	43.3	23.9
Greer et al29	151	NSCLC	Early palliative care	30.0	13.6
Mack et al46	1231	NSCLC and colorectal	Any		16.0
Näppä et al40	374	All	Any	23
Gonsalves et al44	200	All	2002	5
Gonsalves et al44	200	All	2008	18
Ho et al37	227 161	All	1993		2.02
Ho et al37	227 161	All	2003		2.9
Andreis et al59	102	All	Any	16	6
Warren et al53	21 633	All	Patients with OS <6 months	14.8	9
Warren et al53	21 633	All	Patients with OS >6 months	10.2	6.4
Keating et al47	5826	NSCLC and colorectal	VHA cohort		4.6
Keating et al47	5826	NSCLC and colorectal	SEER cohort		7.5
Kao et al62	747	All	Any	18	8.0
Hashimoto et al55	255	All	Any	12.6	3.10
Tang et al28	242 530	All	Trend 2000–2006	16.2
Barbera et al34	5855	All	Any		4.6
Earle et al11	215 484	All	1993		9.70
Earle et al11	215 484	All	1999		11.6
Temel et al36	46	NSCLC	Integrated palliative care	40	23
Yun et al54	3750	All	Any	30.9	22.5
Murillo and Koeller41	417	NSCLC	Any	43	20.0
Earle et al16	28 777	All	1993		13.8
Earle et al16	28 777	All	1996		18.5
Giorgi et al57	193	All	Any	33
Emanuel et al48	7919	All	Massachusetts	9
Emanuel et al48	7919	All	California	9
Aragon-Ching etal56	144	All	Any	26

NR, not reported; NSCLC, non-small cell lung cancer; SEER, Surveillance, Epidemiology and End Results; SOC, standard of care; VHA, Veterans Health Administration.