Table 1

List of the meta-analyses of the adverse events data from the following comparisons: CR oxycodone versus IR oxycodone, CR oxycodone versus CR morphine and CR oxycodone versus TD fentanyl

Outcome and subgroupStudiesCR OXY events/total (%)Comparison events/total (%)Risk ratio (95% CI)I(%)
Any adverse event
 CR OXY versus CR MOR3142/196 (72.4)152/203 (74.9)0.97 (0.87 to 1.09)53
 Asthenia
 CR OXY versus IR OXY25/102 (4.9)9/106 (8.5)0.58 (0.2 to 1.68)30
Confusion
 CR OXY versus IR OXY23/78 (3.8)4/79 (5.1)0.78 (0.2 to 3.02)25
 CR OXY versus CR MOR374/295 (25.1)73/289 (25.3)1.01 (0.78 to 1.31)16
Constipation
 CR OXY versus IR OXY325/156 (16)36/161 (22.4)0.71 (0.45 to 1.13)38
 CR OXY versus CR MOR5139/400 (34.8)141/397 (35.5)0.98 (0.82 to 1.16)33
 CR OXY versus TD FEN288/171 (51.5)80/165 (48.5)1.07 (0.88 to 1.32)83
Dizziness/lightheadedness
 CR OXY versus IR OXY315/156 (9.6)21/161 (13)0.74 (0.4 to 1.37)15
 CR OXY versus CR MOR39/186 (4.8)12/181 (6.6)0.76 (0.33 to 1.76)0
Drowsiness/somnolence
 CR OXY versus IR OXY336/156 (23.1)36/161 (22.4)1.03 (0.69 to 1.54)0
 CR OXY versus CR MOR5121/400 (30.3)134/398 (33.7)0.9 (0.75 to 1.08)0
Dry mouth
 CR OXY versus IR OXY310/156 (6.4)9/161 (5.6)1.14 (0.48 to 2.75)0
 CR OXY versus CR MOR489/343 (25.9)89/341 (26.1)1.01 (0.8 to 1.26)32
Dysuria
 CR OXY versus CR MOR217/186 (9.1)24/186 (12.9)0.71 (0.4 to 1.26)0
 CR OXY versus TD FEN219/171 (11.1)16/165 (9.7)1.15 (0.62 to 2.16)0
Hallucinations
 CR OXY versus CR MOR414/349 (4)27/347 (7.8)0.52 (0.28 to 0.97)0
Headache
 CR OXY versus IR OXY38/156 (5.1)10/161 (6.2)0.83 (0.34 to 2.02)61
Insomnia
 CR OXY versus IR OXY25/132 (3.8)5/137 (3.6)1.04 (0.31 to 3.53)35
Nausea
 CR OXY versus IR OXY332/156 (20.5)39/161 (24.2)0.85 (0.56 to 1.28)0
 CR OXY versus CR MOR5108/400 (27)106/398 (26.6)1.02 (0.82 to 1.26)0
Nervousness
 CR OXY versus IR OXY25/102 (4.9)9/106 (8.5)0.57 (0.2 to 1.64)0
Pruritus
 CR OXY versus IR OXY313/156 (8.3)9/161 (5.6)1.46 (0.65 to 3.25)33
 CR OXY versus CR MOR429/343 (8.5)36/341 (10.6)0.81 (0.51 to 1.29)0
Sweating
 CR OXY versus IR OXY25/132 (3.8)8/137 (5.8)0.65 (0.22 to 1.93)55
Vomiting
 CR OXY versus IR OXY318/156 (11.5)28/161 (17.4)0.66 (0.38 to 1.15)18
 CR OXY versus CR MOR560/400 (15)64/398 (16.1)0.94 (0.68 to 1.29)2
Discontinuation due to adverse events
 CR OXY versus IR OXY311/156 (7.1)19/161 (11.8)0.6 (0.29 to 1.22)0
 CR OXY versus CR MOR39/196 (4.6)9/203 (4.4)1.06 (0.43 to 2.6)48
  • CR, controlled release; FEN, fentanyl; IR, immediate release; MOR, morphine; OXY, oxycodone; TD, transdermal.