RT Journal Article
SR Electronic
T1 Quality of skeletal muscles during allogeneic stem-cell transplantation: a pilot study
JF BMJ Supportive & Palliative Care
JO BMJ Support Palliat Care
FD British Medical Journal Publishing Group
SP spcare-2024-005070
DO 10.1136/spcare-2024-005070
A1 Maeda, Yusaku
A1 Takao, Shoichiro
A1 Morita, Shiori
A1 Kondo, Shin
A1 Yamashita, Michiko
A1 Sumitani, Ryohei
A1 Oura, Masahiro
A1 Sogabe, Kimiko
A1 Takahashi, Mamiko
A1 Fujii, Shiro
A1 Harada, Takeshi
A1 Miki, Hirokazu
A1 Abe, Masahiro
A1 Nakamura, Shingen
YR 2024
UL http://spcare.bmj.com/content/early/2024/09/30/spcare-2024-005070.abstract
AB Objectives This study investigated the muscle fat fraction (FF) and muscle-related parameters before and after allogeneic hematopoietic stem cell transplantation (HSCT).Methods Fat and water signals were derived from the in-phase and out-of-phase MR signal intensities of the pelvis and thigh using the two-point Dixon technique. They were analysed using Synapse Vincent, and muscle quality was evaluated using the FF. The muscle mass was assessed by measuring the thigh and gluteal muscle areas using a manual trace on the MR image. The association between the muscle FF and clinical data was retrospectively determined.Results This study included 11 patients (6 males). Their mean age was 42.7 years, and eight had leukaemia. Eight were assessed at a mean of 65.4 days post-HSCT. The hip and thigh skeletal muscle FFs were not significantly different during HSCT. The grip and lower limb muscle strengths decreased significantly after HSCT. Patients with low FFs before transplantation tended to lose muscle strength, and the increase in FF and decrease of muscle strength were correlated.Conclusions Muscle strength and quantity decrease during the early phase after HSCT, especially in patients with low FF muscles. Therefore, interventions based on muscle quality and quantity are essential.