PT - JOURNAL ARTICLE AU - Kim, Ju Hwan AU - Shen, Chin-Yao AU - Au, Philip Chun-Ming AU - Baek, Yeon-Hee AU - Cheung, Ching-Lung AU - Chung, Wei-Pang AU - Kleinman, Nora Joelle AU - Lam, Tai Chung AU - Liao, Tzu-Chi AU - Lin, Tzu-Chieh AU - Shin, Ju-Young AU - Sing, Chor-Wing AU - Wong, Ian Chi Kei AU - Lai, Edward Chia-Cheng TI - Bone-targeting agents in major solid tumour metastases: a multinational cohort study AID - 10.1136/bmjspcare-2021-003062 DP - 2023 Dec 01 TA - BMJ Supportive & Palliative Care PG - e1064--e1073 VI - 13 IP - e3 4099 - http://spcare.bmj.com/content/13/e3/e1064.short 4100 - http://spcare.bmj.com/content/13/e3/e1064.full SO - BMJ Support Palliat Care2023 Dec 01; 13 AB - Objective To describe the epidemiology, clinical characteristics and utilisation patterns of bone-targeting agents (BTAs) in patients with bone metastases from breast, prostate and lung cancer.Methods This is a multinational retrospective cohort study including patients with three major solid tumours (breast, prostate and lung cancer) and newly initiated on BTAs (ie, denosumab, zoledronic acid and pamidronate). Records were retrieved from nationwide health databases from Hong Kong and Taiwan (HK and TW: 2013–2017) and Korea (KR: 2012–2016). Descriptive analyses included the annual incidence rates of bone metastases and the cumulative incidence curves of BTA initiation. We used Sankey diagrams to visualise the dynamic BTA utilisation patterns.Results The annual incidence rate of bone metastases ranged from 3.5% to 4.5% in TW, from 9.6% to 10.3% in HK and from 2.9% to 3.8% in KR. We identified 14.1% (5127), 9.3% (883) and 9.4% (4800) of patients with bone metastases newly initiated on BTAs in TW, HK and KR, respectively. The most frequently used BTA in TW (67.1%) and HK (51.9%) was denosumab, while in KR (84.8%) it was zoledronic acid. Sankey diagrams indicated the proportion of patients remaining on denosumab was highest in TW and HK, while it was zoledronic acid in KR. Specifically, in TW, patients who were on bisphosphonates or had discontinued treatment frequently switched to or reinitiated denosumab.Conclusions We found the rate of BTA utilisation remained low across all sites and tumour types in recent years. The dynamic utilisation patterns of BTAs provide better understanding of the treatment landscape for future evaluation of associated outcomes of patients.Data may be obtained from a third party and are not publicly available. We used a distributed network approach and executed the analysis independently from each site on the basis of a common protocol. The coordinating centre, the National Cheng Kung University, Taiwan, only collected summary results from each site without access to individual data. The data sets analysed in the current study will not be available to the public due to data privacy regulations in each participating country. Qualified researchers may request data from the corresponding author.