RT Journal Article SR Electronic T1 Quality of life in paediatric solid tumours: a randomised study of metronomic chemotherapy versus placebo JF BMJ Supportive & Palliative Care JO BMJ Support Palliat Care FD British Medical Journal Publishing Group SP 234 OP 237 DO 10.1136/bmjspcare-2020-002731 VO 13 IS 2 A1 Pramanik, Raja A1 Agarwala, Sandeep A1 Sreenivas, Vishnubhatla A1 Dhawan, Deepa A1 Bakhshi, Sameer YR 2023 UL http://spcare.bmj.com/content/13/2/234.abstract AB Objective Health-related quality of life (HRQoL) is an important outcome for paediatric cancer studies. We compared the HRQoL between patients of progressive paediatric solid tumours randomised to metronomic chemotherapy versus placebo.Methods In this double-blinded, placebo-controlled randomised study of 108 children with progressive malignancies, HRQoL was evaluated using the PedsQOL Cancer module V.3 at baseline (A1), A2 (9 weeks or earlier if progressed) or A3 (18 weeks or earlier if progressed).Results There was no statistically significant difference in the change in quality of life produced by each arm from A1 to A2 in either mean total scores or individual domain scores, reported by children or their parents. On analysing the response according to the minimal clinically important difference, defined as an improvement by 4.5 points, we found no significant differences, be it among bone-sarcomas, other tumours, responders (those who received ≥9 weeks of treatment) or non-responders.Conclusions The present study concludes that there was no significant difference in HRQoL, between the patients in the two arms at second and later assessments. This is consistent with the other survival endpoints in the study.Trial registration number Clinical trial registration: clinicaltrials.gov Identifier: NCT01858571.