@article {Javan Biparvabmjspcare-2022-003642, author = {Akbar Javan Biparva and Samira Raoofi and Sima Rafiei and Fatemeh Pashazadeh Kan and Mitra Kazerooni and Farzaneh Bagheribayati and Maryam Masoumi and Maryam Doustmehraban and Mohaddeseh Sanaei and Farnaz Zarabi and Neda Raoofi and Zahra Beiramy Chomalu and Behrooz Ahmadi and Fatemeh Seyghalani Talab and Batool Sadat Hoseini and Elnaz Asadollahi and Maryam Mir and Sama Deylami and Mahsa Zareei and Hadis Sanaei and Fateme Dousti nia Kakavand and Hooman Koohestani and Mahmoud Nasiri and Negin Vali and Ahmad Ghashghaee}, title = {Global quality of life in breast cancer: systematic review and meta-analysis}, elocation-id = {bmjspcare-2022-003642}, year = {2022}, doi = {10.1136/bmjspcare-2022-003642}, publisher = {British Medical Journal Publishing Group}, abstract = {Background Breast cancer (BC) is the most common cancer among women worldwide. We conducted a systematic review and meta-analysis to cover the existing research gap and contribute to existing knowledge to provide both researchers and clinicians with a better profile on the topic and consequently help improve the quality of life (QoL) of patients with BC.Methods A comprehensive review of original articles published in English from January 2000 to October 2021 from databases including Embase, Scopus, PubMed and Web of Science was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.Results Based on the meta-regression which examined a total of 9012 patients with BC, the QoL score calculated by EORTC QLQ-C30 was 64.72 (95\% CI 59.24 to 70.20), while the score obtained from FACT-B was 84.39 (95\% CI 64.24 to 104.54) and the scores from QLQ-BR23 and SF-36 were 66.33 (95\% CI 62.76 to 69.90) and 57.23 (95\% CI 47.65 to 66.82), respectively. A meta-analysis affirmed a significant direct relationship between the QoL score of patients with BC and their age (p=0.03). The results also revealed that the QoL scores of patients who had completed treatment were higher than those who were currently under treatment.Conclusion The present systematic review identified several factors that affect the QoL of women with BC worldwide and provided several implications for developing policy interventions to effectively improve the QoL of women with BC. In this way, clinicians can sufficiently give advice to their patients with the purpose of improving their QoL.PROSPERO registration number CRD42022309791.}, issn = {2045-435X}, URL = {https://spcare.bmj.com/content/early/2022/08/21/bmjspcare-2022-003642}, eprint = {https://spcare.bmj.com/content/early/2022/08/21/bmjspcare-2022-003642.full.pdf}, journal = {BMJ Supportive \& Palliative Care} }