RT Journal Article SR Electronic T1 Cancer survivors and neurotoxic chemotherapy: hearing loss and tinnitus JF BMJ Supportive & Palliative Care JO BMJ Support Palliat Care FD British Medical Journal Publishing Group SP bmjspcare-2022-003684 DO 10.1136/spcare-2022-003684 A1 Steven Cheung A1 Jennifer Henderson-Sabes A1 Judith Mastick A1 Gary Abrams A1 Karin Snowberg A1 Emely Alfaro A1 Marisa Quinn A1 Steven Paul A1 Bruce Cooper A1 Margaret Wallhagen A1 Yvette Conley A1 Jon Levine A1 Christine Miaskowski YR 2022 UL http://spcare.bmj.com/content/early/2022/07/25/spcare-2022-003684.abstract AB Objectives Little is known about hearing loss and tinnitus associated with neurotoxic chemotherapy. Study evaluated for differences in occurrence rates and effects of hearing loss and tinnitus in survivors who received a platinum alone, a taxane alone or a platinum and taxane containing regimen.Methods Total of 273 survivors with breast, gastrointestinal, gynaecological or lung cancer completed self-report measures of hearing loss and tinnitus and had an audiometric assessment that obtained pure tone air conduction thresholds bilaterally at frequencies of between 0.25 kHz to 16.0 kHz. To adjust for age-related and gender-related changes in hearing, each survivor’s audiogram was evaluated using the National Health and Nutrition Examination Survey-modified Occupational Safety and Health Administration standards. Survivor was classified as having hearing loss if at any frequency they scored poorer than the 50th percentile for their age and gender. Survivors were categorised as having tinnitus if they reported that for >10% of their time awake, they were consciously aware of their tinnitus. Differences among the chemotherapy groups were evaluated using parametric and non-parametric tests.Results For most of the demographic and clinical characteristics, no differences were found among the three chemotherapy groups. Occurrence rates for audiogram-confirmed hearing loss ranged from 52.3% to 71.4%. Occurrence rates for tinnitus ranged from 37.1% to 40.0%. No differences were found among the three chemotherapy groups in the occurrence rates or effects of hearing loss and tinnitus.Conclusion These findings suggest that regardless of the chemotherapy regimen common mechanistic pathway(s) may underlie these two neurotoxicities.Data are available on reasonable request.