PT  - JOURNAL ARTICLE
AU  - Javan Biparva, Akbar
AU  - Raoofi, Samira
AU  - Rafiei, Sima
AU  - Pashazadeh Kan, Fatemeh
AU  - Kazerooni, Mitra
AU  - Bagheribayati, Farzaneh
AU  - Masoumi, Maryam
AU  - Doustmehraban, Maryam
AU  - Sanaei, Mohaddeseh
AU  - Zarabi, Farnaz
AU  - Raoofi, Neda
AU  - Beiramy Chomalu, Zahra
AU  - Ahmadi, Behrooz
AU  - Seyghalani Talab, Fatemeh
AU  - Sadat Hoseini, Batool
AU  - Asadollahi, Elnaz
AU  - Mir, Maryam
AU  - Deylami, Sama
AU  - Zareei, Mahsa
AU  - Sanaei, Hadis
AU  - Dousti nia Kakavand, Fateme
AU  - Koohestani, Hooman
AU  - Nasiri, Mahmoud
AU  - Vali, Negin
AU  - Ghashghaee, Ahmad
TI  - Global quality of life in breast cancer: systematic review and meta-analysis
AID  - 10.1136/bmjspcare-2022-003642
DP  - 2022 Jun 16
TA  - BMJ Supportive & Palliative Care
PG  - bmjspcare-2022-003642
4099  - http://spcare.bmj.com/content/early/2022/06/15/bmjspcare-2022-003642.short
4100  - http://spcare.bmj.com/content/early/2022/06/15/bmjspcare-2022-003642.full
AB  - Background Breast cancer (BC) is the most common cancer among women worldwide. We conducted a systematic review and meta-analysis to cover the existing research gap and contribute to existing knowledge to provide both researchers and clinicians with a better profile on the topic and consequently help improve the quality of life (QoL) of patients with BC.Methods A comprehensive review of original articles published in English from January 2000 to October 2021 from databases including Embase, Scopus, PubMed and Web of Science was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.Results Based on the meta-regression which examined a total of 9012 patients with BC, the QoL score calculated by EORTC QLQ-C30 was 64.72 (95% CI 59.24 to 70.20), while the score obtained from FACT-B was 84.39 (95% CI 64.24 to 104.54) and the scores from QLQ-BR23 and SF-36 were 66.33 (95% CI 62.76 to 69.90) and 57.23 (95% CI 47.65 to 66.82), respectively. A meta-analysis affirmed a significant direct relationship between the QoL score of patients with BC and their age (p=0.03). The results also revealed that the QoL scores of patients who had completed treatment were higher than those who were currently under treatment.Conclusion The present systematic review identified several factors that affect the QoL of women with BC worldwide and provided several implications for developing policy interventions to effectively improve the QoL of women with BC. In this way, clinicians can sufficiently give advice to their patients with the purpose of improving their QoL.PROSPERO registration number CRD42022309791.