TY - JOUR T1 - Global health-related quality of life in schizophrenia: systematic review and meta-analysis JF - BMJ Supportive & Palliative Care JO - BMJ Support Palliat Care SP - 123 LP - 131 DO - 10.1136/bmjspcare-2021-002936 VL - 12 IS - 2 AU - Zahra Hoseinipalangi AU - Zahra Golmohammadi AU - Sima Rafiei AU - Fatemeh Pashazadeh Kan AU - Hossein Hosseinifard AU - Sepideh Rezaei AU - Saba Ahmadi AU - Niloofar Ahmadi AU - Samira Raoofi AU - Farnaz Aghajani AU - Afsaneh Dehnad AU - Hosein Shabaninejad AU - Sepideh Aghalou AU - Hamide Shabani AU - Ahmad Ghashghaee Y1 - 2022/06/01 UR - http://spcare.bmj.com/content/12/2/123.abstract N2 - Background and aim Signs and symptoms of schizophrenia may have serious impacts on patients’ quality of life leading to concern about different aspects of their lives. This study presents a systematic review and meta-analysis of the studies examining the quality of life among patients with schizophrenia and its relationship with patients’ characteristics.Materials and methods A total of 40 studies were extracted from searching of relevant databases published between 2000 and 2020. Descriptive data and correlation coefficients between patient’s characteristics and quality of life were extracted and the results were reported according to Preferred Reporting Items for Systematic Reviews and Meta-analyses standards and meta-analysis of pooled studies.Results In total, 8363 patients with schizophrenia participated in 40 studies which used Schizophrenia Quality of Life Scale revision 4. The total score of quality of life (QOL) in the study subjects was reported to be 40.66. Weighted effect size analyses revealed a significant relationship between QOL and variables including patients’ age and duration of the disease. Furthermore, the highest (the worst) score of QOL in schizophrenia patients was observed in Europe 47.04 (95% CI 41.26 to 52.82) and the Euro region 47.05 (95% CI 41.18 to 52.92).Conclusion Overall, the QOL among patients with schizophrenia was in a good status, which could be improved through considering different life aspects of people living in various contexts. In fact, clarifying the determinants of QOL would be a key step in the provision of future treatment efforts.Data are available on reasonable request. This systematic review was conducted based on a registered protocol at PROSPERO (CRD42020213665) available at https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020213665 and was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). ER -