RT Journal Article SR Electronic T1 Fentanyl titration for cancer pain: continuous subcutaneous injection and a once-daily transdermal patch – case series JF BMJ Supportive & Palliative Care JO BMJ Support Palliat Care FD British Medical Journal Publishing Group SP bmjspcare-2022-003720 DO 10.1136/bmjspcare-2022-003720 A1 Tatsuma Sakaguchi A1 Toru Kajiyama A1 Mafumi Miyake A1 Toshiro Katayama YR 2022 UL http://spcare.bmj.com/content/early/2022/05/08/bmjspcare-2022-003720.abstract AB Objectives Continuous subcutaneous injection (CSCI) followed by a once-daily transdermal patch is a reasonable strategy for rapid titration of fentanyl in patients with cancer pain who are unable to take oral medication or have renal impairment, but the effectiveness and safety have not been demonstrated.Methods Medical records of patients with moderate to severe cancer pain who underwent titration of fentanyl by CSCI between October 2019 and October 2021 at Kitano Hospital, Osaka, Japan, were retrospectively reviewed. The dose of fentanyl was increased to a maximum of 0.05 mg/hour. If the dose was inadequate, the fentanyl patch was added on CSCI. When pain relief was adequate, CSCI was completely converted to the patch.Results Thirty-three patients were enrolled. Titration was completed successfully in 28 patients (85%) over a median of 2 days. The average Numeric Rating Scale for pain decreased by at least 66% in 22 patients (67%) and by at least 33% in 7 (21%). After conversion to the patch, two patients (6.1%) required to increase the dose of fentanyl within a week. Two patients (6.1%) experienced moderate drowsiness during titration.Conclusions Fentanyl titration by CSCI is an effective and safe method for achieving rapid pain control.