RT Journal Article SR Electronic T1 Allogeneic haematopoietic stem cell transplantation and patient falls: impact of lower extremity muscle strength JF BMJ Supportive & Palliative Care JO BMJ Support Palliat Care FD British Medical Journal Publishing Group SP bmjspcare-2022-003582 DO 10.1136/bmjspcare-2022-003582 A1 Shin Kondo A1 Tatsuro Inoue A1 Takashi Saito A1 Yuka Kawamura A1 Ayane Katayama A1 Masafumi Nakamura A1 Ryohei Sumitani A1 Mamiko Takahashi A1 Masahiro Oura A1 Kimiko Sogabe A1 Takeshi Harada A1 Shiro Fujii A1 Shingen Nakamura A1 Hirokazu Miki A1 Kumiko Kagawa A1 Nori Sato A1 Rei Ono A1 Masahiro Abe A1 Shinsuke Katoh YR 2022 UL http://spcare.bmj.com/content/early/2022/05/08/bmjspcare-2022-003582.abstract AB Objectives Patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT) have a higher risk of falls than those receiving other therapies for haematological disorders. This study aimed to investigate the impact of pretransplant lower extremity muscle strength (LEMS) on post-transplant falls.Methods In this retrospective cohort study, patients aged ≥18 years who underwent allo-HSCT were included. All data were extracted from medical records. LEMS was defined as the knee extension force measured by a handheld dynamometer divided by the patient’s weight. The receiver operating characteristic (ROC) curve was used to calculate the optimal LEMS cut-off value for prediction of falls. Patients were categorised into low and normal LEMS groups based on the cut-off value. The impact of pretransplant LEMS on post-transplant falls was analysed using a Cox proportional hazards model.Results In total, 101 patients were analysed. During the observation period, falls occurred in 32 patients (31.7%). The ROC curve analysis results showed that the optimal LEMS cut-off value for prediction of falls was 45.4% per body weight. In multivariate analysis, pretransplant low LEMS was a significant predictor of falls in model 1 with patient characteristics as a confounding factor and model 2 with medications-inducing falls as a confounding factor, respectively (model 1: HR 3.23, 95% CI 1.37 to 7.64; model 2: HR 2.82, 95% CI 1.20 to 6.59).Conclusions Pretransplant LEMS was a significant predictor of post-transplant falls. The results of this study may help to prevent falls in patients undergoing allo-HSCT.All data relevant to the study are included in the article or uploaded as supplementary information.