TY - JOUR T1 - Sarcopenia and anthracycline cardiotoxicity in patients with cancer JF - BMJ Supportive & Palliative Care JO - BMJ Support Palliat Care DO - 10.1136/bmjspcare-2021-003197 SP - bmjspcare-2021-003197 AU - Onur Bas AU - Ahmet Gurkan Erdemir AU - Mehmet Ruhi Onur AU - Necla Ozer AU - Yusuf Ziya Sener AU - Salih Aksu AU - Ibrahim Barista AU - Gurkan Guner AU - Deniz Can Guven AU - Neyran Kertmen AU - Sercan Aksoy AU - Alev Turker AU - Omer Dizdar Y1 - 2021/09/03 UR - http://spcare.bmj.com/content/early/2021/09/03/bmjspcare-2021-003197.abstract N2 - Background Several studies have suggested that sarcopenia is associated with an increased treatment toxicity in patients with cancer. The aim of this study is to evaluate the relationship between sarcopenia and anthracycline-related cardiotoxicity.Methods Patients who received anthracycline-based chemotherapy between 2014 and 2018 and had baseline abdominal CT and baseline and follow-up echocardiography after anthracycline treatment were included. European Society of Cardiology ejection fraction criteria and American Society of Echocardiography diastolic dysfunction criteria were used for definition of cardiotoxicity. Sarcopenia was defined on the basis of skeletal muscle index (SMI) and psoas muscle index (PMI) calculated on CT images at L3 and L4 vertebra levels.Results A total of 166 patients (75 men and 91 women) were included. Sarcopenia was determined in 33 patients (19.9%) according to L3-SMI, in 17 patients (10.2%) according to L4-SMI and in 45 patients (27.1%) according to PMI. 27 patients (16.3%) developed cardiotoxicity. PMI and L3-SMI were significantly associated with an increased risk of cardiotoxicity (L3-SMI: HR=3.27, 95% CI 1.32 to 8.11, p=0.01; PMI: HR=3.71, 95% CI 1.58 to 8.73, p=0.003).Conclusions This is the first study demonstrating a significant association between CT-diagnosed sarcopenia and anthracycline-related cardiotoxicity. Routine CT scans performed for cancer staging may help clinicians identify high-risk patients in whom closer follow-up or cardioprotective measures should be considered.Data are available upon reasonable request. The data that support the findings of this study are available from the corresponding author upon reasonable request. ER -