RT Journal Article SR Electronic T1 Hemodialysis and peritoneal dialysis—health-related quality of life: systematic review plus meta-analysis JF BMJ Supportive & Palliative Care JO BMJ Support Palliat Care FD British Medical Journal Publishing Group SP bmjspcare-2021-003182 DO 10.1136/bmjspcare-2021-003182 A1 Samira Raoofi A1 Fatemeh Pashazadeh Kan A1 Sima Rafiei A1 Zahra Hoseinipalangi A1 Sepide Rezaei A1 Saba Ahmadi A1 Maryam Masoumi A1 Zahra Noorani Mejareh A1 Mahshid Roohravan Benis A1 Alireza Sharifi A1 Hosein Shabaninejad A1 Zahra Mansour Kiaee A1 Ahmad Ghashghaee YR 2021 UL http://spcare.bmj.com/content/early/2021/07/22/bmjspcare-2021-003182.abstract AB Background Patients with end-stage renal disease undergoing haemodialysis experience a variety of stressors leading to decreased level of quality of life (QoL). Thus, in this study, we aimed to review the current literature and identify factors affecting the health-related QoL (HRQoL) in these patients.Methods A total of 147 studies were extracted from databases of Web of Science, PubMed, Scopus, Google Scholar, and Embase published between January 2000 and December 2020. Data were analysed using R software and results were reported with reference to Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards.Results A total of 623 728 patients undergoing dialysis participated in 147 studies in which QoL was assessed by means of two valid questionnaires, including Short-Form 36 (SF-36) and Kidney Disease Quality of Life (KDQOL)-short form V.1.3. Total HRQoL score for patients undergoing dialysis measured by KDQOL was 64.25 (95% CI 55.67 to 72.82). Based on SF-36, the mean score of mental health items was higher than the mean score of physical health condition. Furthermore, meta-regression based on the geographical place of residence revealed that the highest QoL in patients was observed in Japan, 66.96 (95% CI 63.65 to 70.28) and Brazil, 58.03 (95% CI 53.45 to 62.6).Conclusion Studies conducted on HRQoL among patients undergoing dialysis recommend useful strategies to clinicians, letting them assess patients’ QoL in terms of a wide range of physical, mental and environmental aspects.