PT - JOURNAL ARTICLE AU - Tan, Ting Ting AU - Tan, Maw Pin AU - Lam, Chee Loong AU - Loh, Ee Chin AU - Capelle, David Paul AU - Zainuddin, Sheriza Izwa AU - Ang, Bin Ting AU - Lim, Min Ai AU - Lai, Natalie Zi AU - Tung, Yu Zhen AU - Yee, Hway Ann AU - Ng, Chong Guan AU - Ho, Gwo Fuang AU - See, Mee Hoong AU - Teh, Mei Sze AU - Lai, Lee Lee AU - Pritam Singh, Ranjit Kaur AU - Chai, Chee Shee AU - Ng, Diana Leh Ching AU - Tan, Seng Beng TI - Mindful gratitude journaling: psychological distress, quality of life and suffering in advanced cancer: a randomised controlled trial AID - 10.1136/bmjspcare-2021-003068 DP - 2021 Jul 08 TA - BMJ Supportive & Palliative Care PG - bmjspcare-2021-003068 4099 - http://spcare.bmj.com/content/early/2021/07/07/bmjspcare-2021-003068.short 4100 - http://spcare.bmj.com/content/early/2021/07/07/bmjspcare-2021-003068.full AB - Context Numerous studies have shown that gratitude can reduce stress and improve quality of life.Objective Our study aimed to examine the effect of mindful gratitude journaling on suffering, psychological distress and quality of life of patients with advanced cancer.Methods We conducted a parallel-group, blinded, randomised controlled trial at the University of Malaya Medical Centre, Malaysia. Ninety-two adult patients with advanced cancer, and an overall suffering score ≥4/10 based on the Suffering Pictogram were recruited and randomly assigned to either a mindful gratitude journaling group (N=49) or a routine journaling group (N=43).Results After 1 week, there were significant reductions in the overall suffering score from the baseline in both the intervention group (mean difference in overall suffering score=−2.0, 95% CI=−2.7 to −1.4, t=−6.125, p=0.000) and the control group (mean difference in overall suffering score=−1.6, 95% CI=−2.3 to −0.8, t=−4.106, p=0.037). There were also significant improvements in the total Hospital Anxiety and Depression Scale score (mean difference=−3.4, 95% CI=−5.3 to −1.5, t=−3.525, p=0.000) and the total Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being score (mean difference=7.3, 95% CI=1.5 to 13.1, t=2.460, p=0.014) in the intervention group after 7 days, but not in the control group.Conclusion The results provide evidence that 7 days of mindful gratitude journaling could positively affect the state of suffering, psychological distress and quality of life of patients with advanced cancer.Trial registration number The trial was registered with the Australian and New Zealand Clinical Trials Registry (ACTRN1261800172191) and conducted in accordance with the Declaration of Helsinki.Data are available on reasonable request. Data are kept as hardcopy and soft copy by the authors.