Article Text

Download PDFPDF
Chronic fatigue syndrome post-COVID-19: triple-blind randomised clinical trial of Astragalus root extract
  1. Zahra-Sadat Banihashemi1,
  2. Ismail Azizi-Fini1,
  3. Mahdi Rajabi2,
  4. Mahboobeh Maghami3 and
  5. Safoura Yadollahi1
  1. 1Trauma Nursing Research Center, Kashan University of Medical Sciences, Kashan, Isfahan, Iran
  2. 2Department of Anesthesiology, Kashan University of Medical Sciences, Kashan, Iran
  3. 3Department of Biostatistics and Epidemiology, Isfahan University of Medical Sciences, Isfahan, Iran
  1. Correspondence to Dr Safoura Yadollahi, Trauma Nursing Research Center, Kashan University of Medical Sciences, Kashan, Isfahan, Iran; yadollahi.safoura{at}


Objective This study aimed to evaluate the effect of Astragalus root extract on nurses suffering from post-COVID-19 chronic fatigue syndrome.

Materials and methods The study was designed as a triple-blind, randomised, controlled trial in Iran in 2023. 64 chronic fatigue syndrome nurses were randomly assigned to one of two groups: an intervention group (n=32) that received Astragalus root extract (500 mg two times per day) or a control group (n=32) that received a placebo. Changes in chronic fatigue syndrome scores were measured before to, at the end of and 1 month after the intervention. Data were analysed using descriptive and analytical statistics (T-tests, χ2, analysis of variances, Cochran’s Q tests, McNemar and generalised estimating equations).

Results In comparison to before, chronic fatigue prevalence decreased statistically significantly at the end of the intervention group (13.8%) and 1 month later (17.2%). Further, the frequency differed between before and after (p=0.0001) and 1 month later (p=0.0001). In the control group, chronic fatigue was statistically significantly different before and after the intervention (72.2%; p=0.003). Having an underlying disease (B=0.84, OR=2.33; p=0.04) and being in the control group (B=2.15, OR=12.36; p=0.01) increased the risk of chronic fatigue, whereas increasing the length of time decreased it (B=−0.67, OR=0.50; p=0.0001).

Conclusion Astragalus root extract has been shown to reduce chronic fatigue in nurses. Therefore, this herbal extract can be used to reduce the incidence and treatment of chronic fatigue in nurses.

  • COVID-19
  • Fatigue
  • Chronic conditions
  • Complementary therapy

Data availability statement

No data are available.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Data availability statement

No data are available.

View Full Text


  • Contributors IA-F: writing–review and editing, project administration, methodology, investigation, funding acquisition, conceptualisation. SY: writing–review and editing, writing–original draft, supervision, methodology, funding acquisition, formal analysis, conceptualisation. Z-SB: writing–review and editing, writing–original draft, methodology, funding acquisition, conceptualisation. MM: writing–review and editing, writing–original draft, formal analysis. MR: writing–review and editing, methodology, funding acquisition, conceptualisation. SY accepts full responsibility for the work and/or theconduct of the study, had access to the data, and controlled thedecision to publish.

  • Funding This work was supported by the Kashan University of Medical Science (grant number: 401164).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.