Article Text

Download PDFPDF
Hemodialysis and peritoneal dialysis—health-related quality of life: systematic review plus meta-analysis
  1. Samira Raoofi1,
  2. Fatemeh Pashazadeh Kan2,
  3. Sima Rafiei3,
  4. Zahra Hoseinipalangi4,
  5. Sepide Rezaei1,
  6. Saba Ahmadi4,
  7. Maryam Masoumi5,
  8. Zahra Noorani Mejareh6,
  9. Mahshid Roohravan Benis6,
  10. Alireza Sharifi7,
  11. Hosein Shabaninejad8,
  12. Zahra Mansour Kiaee9 and
  13. Ahmad Ghashghaee10
  1. 1Student Research Committee, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  2. 2Health Management and Economics Research Center, Health Management Research Institute, Iran University of Medical Sciences, Tehran, Iran
  3. 3Social Determinants of Health Research Center, Qazvin University of Medical Sciences, Qazvin, Iran (the Islamic Republic of)
  4. 4Student Research Committee, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  5. 5Clinical Research and Development Center, Qom University of Medical Sciences, Qom, Iran
  6. 6Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7Student Research Committee, Qom University of Medical Sciences, Qom, Tehran, Iran (the Islamic Republic of)
  8. 8Population Health Sciences Institute (PHSI), Newcastle University, Newcastle, UK
  9. 9Independent Researcher, Newcastle, UK
  10. 10Student Research Center, Qazvin university of medical sciences, Qazvin, Iran
  1. Correspondence to Mr Ahmad Ghashghaee, Iran University of Medical Sciences, Tehran, Iran (the Islamic Republic of); ahmad.ghashghaee1996{at}


Background Patients with end-stage renal disease undergoing haemodialysis experience a variety of stressors leading to decreased level of quality of life (QoL). Thus, in this study, we aimed to review the current literature and identify factors affecting the health-related QoL (HRQoL) in these patients.

Methods A total of 147 studies were extracted from databases of Web of Science, PubMed, Scopus, Google Scholar, and Embase published between January 2000 and December 2020. Data were analysed using R software and results were reported with reference to Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards.

Results A total of 623 728 patients undergoing dialysis participated in 147 studies in which QoL was assessed by means of two valid questionnaires, including Short-Form 36 (SF-36) and Kidney Disease Quality of Life (KDQOL)-short form V.1.3. Total HRQoL score for patients undergoing dialysis measured by KDQOL was 64.25 (95% CI 55.67 to 72.82). Based on SF-36, the mean score of mental health items was higher than the mean score of physical health condition. Furthermore, meta-regression based on the geographical place of residence revealed that the highest QoL in patients was observed in Japan, 66.96 (95% CI 63.65 to 70.28) and Brazil, 58.03 (95% CI 53.45 to 62.6).

Conclusion Studies conducted on HRQoL among patients undergoing dialysis recommend useful strategies to clinicians, letting them assess patients’ QoL in terms of a wide range of physical, mental and environmental aspects.

  • quality of life
  • supportive care

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Correction notice This article has been updated since it was first published. The article type has been changed to Systematic review.

  • Contributors Category 1: Conception and design of the study—ZH, AG, FPK and SR. Acquisition of data—ZH, AG, FPK, SR, SA and MM. Analysis and/or interpretation of data—SR, ZH, MRB, SR and HS. Category 2: Drafting the manuscript—ZH, AG, ZNM and ZMK. Revising the manuscript critically for important intellectual content—ZH, AG, FPK, SR and AS. Approval of the version of the manuscript to be published—ZH, AG, FPK and SR.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.