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Dantrolene for muscle rigidity in progressive supranuclear palsy
  1. Nadia Khan
  1. Palliative Medicine, John Taylor Hospice, Birmingham, Birmingham, UK
  1. Correspondence to Dr Nadia Khan, John Taylor Hospice, Birmingham, Birmingham, UK; nadia.khan28{at}


Progressive supranuclear palsy is a degenerative neurological condition with a high level of associated motor symptom burden manifesting in poor postural reflexes, bradykinesia, dystonia and stiffness in the body core and neck. In the light of a paucity in literature exploring pain management in neurodegenerative diseases, the below case report describes the use of dantrolene to successfully relieve distressing widespread dystonia and muscle rigidity refractory to non-pharmacological and pharmacotherapy. To our knowledge, this is the first reported case of dantrolene use for the treatment of refractory muscle rigidity pain in neurodegenerative conditions.

  • neurological conditions
  • symptoms and symptom management

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  • Collaborators Joanne Bartlett.

  • Contributors Nadia Khan authored the case report. Joanne Bartlett provided proofreading.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.