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Extreme opioid-induced constipation in advanced cancer: successful management
  1. Sebastiano Mercadante1 and
  2. Marina Gueci2
  1. 1Pain Relief and Supportive Care, La Maddalena, Palermo, Italy
  2. 2Home Palliative Care, SAMOT, Palermo, Italy
  1. Correspondence to Dr Sebastiano Mercadante, Pain Relief and Supportive Care, La Maddalena, Palermo 90145, Italy; terapiadeldolore{at}


Unrecognised and untreated constipation may be a serious risk for complications, including definitive obstruction due to faecal impact or perforation due to the hypertensive intraluminal state. An intensive approach in an acute supportive palliative care unit may resolve the clinical picture allowing the resumption of intestinal transit in a short period of time.

  • pain
  • constipation

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  • Contributors Authors shared all the commitments.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.