Objective We aimed to investigate the association of fatigue with severity of other key cancer symptoms, as well as symptom interference with daily activities and outlook on life, in long-term survivors of acute promyelocytic leukaemia (APL).
Methods The study sample consisted of APL survivors (n=244), with a median time from diagnosis of 14.3 years (IQR=11.1–16.9 years), previously enrolled in a long-term follow-up study. Symptom severity and symptom interference were assessed using the well-validated MD Anderson Symptom Inventory (MDASI). Fatigue was evaluated with the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaire.
Results Higher fatigue burden was associated with increased affective symptoms, memory problems, drowsiness, sleep disturbances, shortness of breath and pain. Higher levels of fatigue were also associated with higher scores across all interference items of the MDASI. Overall, symptoms interfered most with mood, but among APL survivors with high levels of fatigue, symptoms interfered most with enjoyment of life. Multivariable regression analysis confirmed the independent association between fatigue and all symptom severity items of the MDASI.
Conclusions The current findings show that long-term APL survivors who report higher fatigue also experience a greater overall symptom burden and a substantial impact on performance of daily activities. Further studies are needed to examine whether interventions aimed at reducing fatigue could also reduce overall symptom burden.
- quality of life
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Contributors FE and FC contributed to the design of the research study. FC and KS performed the analysis. KS prepared the first draft of the manuscript. KS, MV, FC, MB, OA, ML, TI, EB, PC, FR, FF, CR, MS, BM, MC and FE were involved in the interpretation of the results and have approved the final submitted version of the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests The following authors declare competing interests unrelated to this work: FE: consultancy for Amgen, Bristol Myers Squibb, Orsenix, and Takeda, and research grants (to his institution) from Amgen. FR: advisory board/speakers’ bureau for Amgen, Novartis and Argenx. MC: Novartis and Incyte. MB: honoraria by Novartis, Incyte, Pfizer and Celgene. ML: advisory board for Novartis, Gilead Sci, MSD, Jazz, Sanofi, Daiichi Sankyo and AbbVie, and travel grant (Gilead Sci). EB: consultancy for Amgen and Celgene. MV: personal fees from Jazz Healthcare Italy, Amgen, Millennium Pharmaceuticals, Celgene, Janssen, Novartis and Incyte.
Patient consent for publication Not required.
Ethics approval Study approval was obtained from the ethical committee of each participating centre.
Provenance and peer review Not commissioned; externally peer reviewed.
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