Cancer cachexia is a multifactorial syndrome characterised by an ongoing loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support alone. Cachexia has a high prevalence in cancer and a major impact on patient physical function, morbidity and mortality. Despite the consequences of cachexia, there is no licensed treatment for cachexia and no accepted standard of care. It has been argued that the multifactorial genesis of cachexia lends itself to therapeutic targeting through a multimodal treatment. Following a successful phase II trial, a phase III randomised controlled trial of a multimodal cachexia intervention is under way. Termed the MENAC trial (Multimodal—Exercise, Nutrition and Anti-inflammatory medication for Cachexia), this intervention is based on evidence to date and consists of non-steroidal anti-inflammatory drugs and eicosapentaenoic acid to reduce inflammation, a physical exercise programme using resistance and aerobic training to increase anabolism, as well as dietary counselling and oral nutritional supplements to promote energy and protein balance. Herein we describe the development of this trial.
Trial registration number NCT02330926.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
30 TSS and BJAL are joint first authors.
32 SK and KF are joint senior authors.
Contributors TS, BL, SK and KF led the manuscript writing. KF conceptualised the MENAC trial. TB, AB, GS, VB, MM, MF, FS and GG had significant input in manuscript preparation. All authors approved the submitted manuscript.
Funding UK: Marie Curie, Pancreatic Cancer UK and the Rising Tide Foundation funded the MENAC trial.
Competing interests None declared.
Ethics approval Ethical approval was not required for this article; however, ethical and regulatory approval has been given for the MENAC trial.
Provenance and peer review Not commissioned; externally peer reviewed.