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Time to revisit ‘Megace’ for hot flushes in patients with breast cancer?
  1. Mei-Lin Ah-See
  1. Breast Unit, Mount Vernon Cancer Centre, Northwood, UK
  1. Correspondence to Dr Mei-Lin Ah-See, Breast Unit, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood HA6 2RN, UK; m.ah-see{at}

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The NICE guidance on menopause management was eagerly awaited but when it was released in November 20151 it came as a disappointment to many patients with breast cancer struggling with menopausal symptoms, in particular those suffering with hot flushes.

For this patient group, hormone replacement therapy (HRT) is contraindicated, especially on the back of the HABITS study which demonstrated a threefold increased risk of a new breast cancer event with HRT,2 although interestingly only 21% of patients were on concurrent tamoxifen therapy at the time within this study. The new 2015 NICE guidance refers patients with breast cancer and their clinicians back to the old 2009 NICE …

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