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O-13 The CARiAD study
  1. Marlise Poolman,
  2. Jessica Roberts,
  3. Julia Hiscock,
  4. Annie Hendry,
  5. Stella Wright and
  6. Clare Wilkinson
  1. Bangor University, Wrexham, UK


CARer-ADministration of as-needed sub-cutaneous medication for breakthrough symptoms in homebased dying patients: a UK study (CARiAD)

Background While the majority of seriously ill people wish to die at home, only half achieve this. The likelihood of someone dying at home often depends on the availability of able and willing lay carers to support them. Whilst this often involves giving medication, people in the last days of life may be unable to take oral medication. Regular medications can be administered using a syringe driver. When top-up medication is required for breakthrough symptoms, a clinician must travel to the home to administer as-needed subcutaneous medication.

Aims To determine if carer-administration of as-needed subcutaneous medication for four frequent breakthrough symptoms (pain, nausea, restlessness and noisy breathing) in home-based dying patients is feasible and acceptable in the UK.

Methods Adult patients anticipated to be in the last weeks of life who were likely to lose the oral route and expressed a preference to die at home were recruited with their carers to an external randomised pilot trial across three UK sites (North Wales, South Wales and Gloucestershire). Patient/Carer dyads randomised to the intervention arm received a manualised training package delivered by their community nursing teams. Dyads in the control arm received usual care. Carers in both arms completed carer diaries and outcome measures.

Results Forty dyads were recruited. The main outcomes of interest are feasibility, acceptability, recruitment rates, attrition and selection of the most appropriate outcomes measures.

Conclusions Findings will inform a definitive Phase III randomised controlled trial.

This study is funded by the National Institute for Health Research (NIHR) HTA (Grant Reference Number 15/10/37). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care.

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