Article Text

Download PDFPDF
Prolonged survival with maintenance pemetrexed for a multiple primary malignancy
  1. Md Shuayb and
  2. Md Salim Reza
  1. Square Oncology and Radiotherapy Centre, Square Hospitals, Dhaka, Bangladesh
  1. Correspondence to Dr Md Shuayb, Square Oncology and Radiotherapy Centre, Square Hospitals Ltd, Dhaka 1205, Bangladesh; m.shuayb{at}


Despite the fact that multiple primary malignancies (MPMs) are not new and have been diagnosed for about a hundred-year time, literatures on lung and colon primaries are scarce. We report a case of a 62-year-old Asian Bangladeshi man with stage IV lung adenocarcinoma who developed a metachronous stage II colon adenocarcinoma approximately 3 years later. A chemotherapy protocol of six cycles of pemetrexed/cisplatin followed by maintenance pemetrexed was used, and surgery was done for the colon primary. With more than 5 years of periodic follow-up, his disease remains stable without any local or metastatic recurrence. Definitive therapeutic protocols are unavailable, but information taken with caution from case reports may be of importance for treatment decisions of MPMs. We believe that management with careful judgement by a multidisciplinary team may result in a good outcome with longer survival.

  • multiple primary malignancies
  • double malignancy
  • lung cancer
  • colon cancer
  • maintenance pemetrexed
  • pemetrexed

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors MS was responsible for acquisition of clinical information from the patient and wrote the manuscript. MSR was the primary oncologist and was involved in the clinical management of the patient. Both authors read and approved the final manuscript.

  • Funding There was no specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • Correction notice This article has been corrected since it published Online First. The first sentence in the second paragraph of the Case Presentation section has been corrected.