Hospitalisation in protected/isolated rooms is a measure, frequently, adopted for hematological patients undergoing to intensive treatment, such as allogeneic (allo) or autologous (auto) stem cell transplantation (SCT), due to a high risk of infections.1 However, the level of evidence about the efficacy of isolation measure during SCT is poor, thus resulting in discrepancy between different centres.1 Prolonged isolation affects quality of life, due to restriction of socio-familiar role and lack of psychological relieve of patients, thus increasing the high burden of symptoms reported by transplanted patients during the first weeks after SCT.2–6 Moreover, isolation could affect psychological status of patient relatives, such as children, frequently not allowed to visit their parent during hospitalisation. Isolation effects on patient undergoing to SCT could …