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Carbamazepine, oxcarbazepine and eslicarbazepine risk of serious skin reactions
The UK Medicines and Healthcare products Regulatory Agency (MHRA) has highlighted the risk of serious skin reactions, including Stevens-Johnson syndrome, with carbamazepine, oxcarbazepine and eslicarbazepine in patients with European descent or Japanese origin who have the HLA-A*3101 genetic marker. The risk of serious skin reactions with these drugs is already known to be associated with patients of Asian origin who have the genetic marker HLA-B*1502, and screening is recommended for patients of Han Chinese or Thai origin before treatment with these drugs.
There are currently insufficient data to support screening for the HLA-A*3101 genetic marker before treatment. Current advice is that …
Competing interests None.
Provenance and peer review Not commissioned; internally peer reviewed.