Article Text
Abstract
Objective This study investigated whether baseline or alteration in muscle mass affects complications during chemotherapy or overall survival (OS) in haematological malignancies.
Methods Skeletal Muscle Index (SMI) was evaluated by bioimpedance analysis before and after chemotherapy in patients with haematological malignancies, and the association between muscle mass and clinical data was retrospectively analysed.
Results Exactly 104 patients were enrolled, with a mean age of 62.2 years. SMI was 7.85 and 6.08 in male and female patients under 65 years and 7.10 and 5.92 over 65 years, before chemotherapy, respectively. Lower baseline SMI was not correlated with worse OS in total patients (p=0.915). After a median measurement interval of 30 days after chemotherapy (n=67), body weight and SMI decreased by 2.73% and 2.87% (mean), respectively. The decrease in body weight correlated with the loss of trunk muscle mass (R2=0.2107) but was more strongly associated with the loss of lower limbs muscle mass (R2=0.3985). The muscle mass of lower limbs significantly decreased in lymphoma patients who experienced febrile neutropenia (−0.42% vs −6.04%, p=0.040). OS significantly decreased in lymphoma patients with loss of lower limbs muscle ≥2.8% (p=0.0327).
Conclusions Muscle loss occurred following anticancer treatments, significantly contributing to worse outcomes. Body composition assessment and relevant multimodal prevention of muscle loss may be vital for patients receiving chemotherapy for haematological malignancies.
- Lymphoma
- Rehabilitation
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Footnotes
Contributors Conceptualisation: MT, SK and SN; Data acquisition and processing: MT, KK, SN and SK; Clinical work for the patient: MT, SN, KK, MN, YM, RS, HY, MO, KS, TH, SF and HM; Writing—original draft preparation: MT and SN; Writing—revised draft and editing: IE and MA; Manuscript supervision: IE and MA; Project administration: MT and SN. All authors have read and agreed to the published version of the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests MA received research funding from Chugai Pharmaceutical and Sanofi; KK from Pfizer; Seiyaku KK and Kyowa Hakko Kirin from Janssen Pharma; KK from Takeda Pharmaceutical, Teijin Pharma, Ono Pharmaceutical and honoraria from the Daiichi Sankyo Company. SN and MT declare no conflicts of interest.
Provenance and peer review Not commissioned; internally peer reviewed.
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