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Dual opioid therapy in a cancer patient with myasthenia gravis who developed respiratory depression from codeine
  1. Sebastiano Mercadante,
  2. Claudio Adile and
  3. Patrizia Ferrera
  1. Main regional center Pain Relief and Supportive Care Unit, La Maddalena Cancer Center, Palermo, Italy
  1. Correspondence to Dr Sebastiano Mercadante, pain relief and supportive care, La Maddalena, Palermo 312, 90146, Italy; terapiadeldolore{at}


This case report describes a patient who was referred to our unit after an emergency room admission for respiratory depression induced by codeine, and was successfully managed with tapentadol.

  • cancer
  • pain
  • pharmacology
  • neurological conditions

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  • Contributors All authors equally contributed to this work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.