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Physical activity and health-related quality of life in multiple myeloma survivors: the PROFILES registry
  1. Michela Servadio1,
  2. Francesco Cottone1,
  3. Kathrin Sommer1,
  4. Simone Oerlemans2,
  5. Lonneke van de Poll-Franse2,3,4 and
  6. Fabio Efficace1
  1. 1 Data Center and Health Outcomes Research Unit, Italian Group for Adult Hematologic Diseases (GIMEMA), Rome, Italy
  2. 2 Department of Research, Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands
  3. 3 Department of Medical and Clinical Psychology, Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg, the Netherlands
  4. 4 Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands
  1. Correspondence to Dr Michela Servadio, Data Center and Health Outcomes Research Unit, Italian Group for Adult Hematologic Diseases (GIMEMA), Roma 00161, Italy; m.servadio{at}


Objectives To investigate whether physical activity (PA) is associated with health-related quality of life (HRQOL) outcomes in multiple myeloma (MM) survivors up to 11 years after diagnosis.

Methods We used data from the Patient Reported Outcomes Following Initial treatment and Long term Evaluation of Survivorship registry. We included 175 MM survivors diagnosed between 1999 and 2009 as registered by the Netherlands Cancer Registry. Sixty-four per cent (n=112/175) of patients who received the questionnaires, completed the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and the EORTC QLQ-MY20. Patients were classified into two groups: physically active and not physically active patients. Univariable and multivariable linear regression models were used to evaluate associations between PA and HRQOL outcomes.

Results Physically active patients reported a statistically significant higher global health status/HRQOL (p=0.001), lower fatigue (p=0.002) and fewer side effects of treatments (p=0.001), than not physically active patients. PA was not associated with psychological symptoms (ie, anxiety and depressive symptoms) (anxiety: p=0.139; depressive symptoms: p=0.073). Exploratory analyses performed on the other scales of the EORTC QLQ-C30 indicated statistically significant better outcomes in several functional and symptom subscales for physically active patients.

Conclusions These findings might contribute to a better understanding of the relationship between PA and disease specific HRQOL aspects in MM survivors. Prospective studies are warranted to further elucidate on the beneficial effects of PA on HRQOL outcomes of MM survivors.

  • quality of life
  • survivorship
  • haematological disease

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  • Contributors Study concept and design: MS, FE, FC, KS. Acquisition of data: LvdP, SO. Statistical analysis: FC, KS. Interpretation of data: all authors. Drafting of the manuscript or revision for important intellectual content: all authors.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests Author FE has received personal fees for consulting from Bristol-Myers Squibb, Amgen, Orsenix and Incyte unrelated to this work. The remaining authors declare that they have no competing interests.

  • Patient consent for publication Not required.

  • Ethics approval Approval for the study was obtained from a local, certified Medical Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Data are available upon reasonable request. Data may be obtained from a third party and are not publicly available.