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Cancer immunotherapy and toxic epidermal necrolysis
  1. Liyan Zhang1,
  2. Lin Shen1,
  3. Yuhan Lu2 and
  4. Jing Xue1
  1. 1 The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Medical Oncology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China
  2. 2 The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Nursing Department, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China
  1. Correspondence to Professor Lin Shen, The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Medical Oncology, Peking University School of Oncology, Beijing Cancer Hospital, Beijing, Beijing 100142, China; linshenpku{at}163.com

Abstract

Objectives Immunotherapy has come to play an increasingly important role in cancer treatment. Accordingly, immune-related adverse events (irAEs) have drawn considerable attention. In this case, a young female patient developed immune-related toxic epidermal necrolysis (TEN). The same irAEs have been rarely reported in previous studies. In this study, we describe the treatment and care methods used in this case in detail in order to provide a reference for clinical practice.

Methods After being diagnosed with TEN, the patient accepted systemic glucocorticoid therapy, timely care of skin and mucous membranes, nutrition support, antiacid therapy, anti-inflammatory, analgesics and other supportive measures.

Results The patient’s skin recovered completely, and no serious adverse outcomes, such as secondary infection or multiple organ failure, occurred during treatment.

Conclusion Medical staff should be able to identify the performance of rare irAEs such as TENs and actively explore comprehensive treatments to ensure patient safety and avoid adverse outcomes.

  • cancer
  • gastrointestinal (upper)
  • skin care
  • supportive care

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Footnotes

  • Contributors LZ conducted the case nursing and paper writing and was responsible for the overall content as guarantor. LS planned and guided the practice process and revised the paper. YL also gave a lot of advice on the nursing practice. JX did a huge work in the translating.

  • Funding This study was funded by Peking University; grand number (HRHL19MS03).

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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